中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
10期
40-41
,共2页
李晓波%李燕%李亚平%王卫%周英%邓紫玉%屈晓雯%唐慧
李曉波%李燕%李亞平%王衛%週英%鄧紫玉%屈曉雯%唐慧
리효파%리연%리아평%왕위%주영%산자옥%굴효문%당혜
MTHFR基因多态性%ACI
MTHFR基因多態性%ACI
MTHFR기인다태성%ACI
MTHFR%Polymorphism%ACI
目的 探讨MTHFR基因多态性与老年动脉粥样硬化性脑梗死(ACI)的关系.方法 应用PCR-RFLP检测88例ACI患者及31例对照组MTHFR基因多态性.结果 ACI组与对照组MTHFR基因C677T位点各基因型频率、T等位基因频率、T/T纯合子频率差异无显著统计学差异.结论 老年患者MTHFR基因C677T突变的纯合子与ACI无显著关系,不能被确定为老年ACI的独立危险因素.
目的 探討MTHFR基因多態性與老年動脈粥樣硬化性腦梗死(ACI)的關繫.方法 應用PCR-RFLP檢測88例ACI患者及31例對照組MTHFR基因多態性.結果 ACI組與對照組MTHFR基因C677T位點各基因型頻率、T等位基因頻率、T/T純閤子頻率差異無顯著統計學差異.結論 老年患者MTHFR基因C677T突變的純閤子與ACI無顯著關繫,不能被確定為老年ACI的獨立危險因素.
목적 탐토MTHFR기인다태성여노년동맥죽양경화성뇌경사(ACI)적관계.방법 응용PCR-RFLP검측88례ACI환자급31례대조조MTHFR기인다태성.결과 ACI조여대조조MTHFR기인C677T위점각기인형빈솔、T등위기인빈솔、T/T순합자빈솔차이무현저통계학차이.결론 노년환자MTHFR기인C677T돌변적순합자여ACI무현저관계,불능피학정위노년ACI적독립위험인소.
Objective To investigate the relationship of polymorphisms in MTHFR and atherosclerotic cerebral infarction(ACI)in the elderly.Methods PCR-RFLP was used to analyze the MTHFR C677T genotypes in a sample of 88 cases with documented ACI and 31 controls among the elderly patients.Results There were no differences in genotype frequency or allele frequencies between ACI and the control.Conclusion MTHFR gene mutation cannot ascertained to be independent risk of atherosclerotic cerebral infarction in the elderly.
