中国中西医结合杂志(英文版)
中國中西醫結閤雜誌(英文版)
중국중서의결합잡지(영문판)
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2002年
3期
172-174
,共3页
邓云坤%李正伦%申天海%杨世虞%阎兴治%张大国%刘秀伦
鄧雲坤%李正倫%申天海%楊世虞%閻興治%張大國%劉秀倫
산운곤%리정륜%신천해%양세우%염흥치%장대국%류수륜
Ginkgo biloba extract%ischemic-reperfusion injury%myocardial protection
Objective: To observe the myocardial protecting effects of Ginaton (Ginkgo biloba extract) on ischemic-reperfusion injured myocardium during cardiopulmonary bypass (CPB). Methods: Twenty patients selected undergoing mitral valvular replacement were randomly divided into two groups. Control group: 10 patients, intermittent intra-aortic infusion with cold St.Thomas solution during hypothermic CPB. Ginaton group: 10 patients, intermittent intra-aortic infusion with cold St. Thomas solution containing Ginaton (0.5 mg*kg-1). Changes of ultrastructure levels of adenosine triphosphate (ATP), malondialdehyde (MDA) and hemodynamic data were measured. Results: Hemodynamic parameters in the Ginaton group were maintained better than those in the control group. MDA in the control group was significantly elevated during ischemic-reperfusion (P<0.05), while in the Ginaton group, there were no obvious change. The levels of ATP and energy change in the Ginaton group were obviously higher than those in the control group at declamping aorta (P<0.05). The percentage of normal mitochondria and glycogen content were significantly higher in the Ginaton group than that in the control group at declamping aorta (P<0.05). Conclusion: Ginkgo biloba extract may provide a beneficial effect on myocardial protection in ultrastructural preservation, prevention of high energy phosphate depletion, reduction in free radicals production and improvement of myocardial function.