西藏林芝地区肾综合征出血热自然疫源地 血清流行病学调查
서장림지지구신종합정출혈열자연역원지 혈청류행병학조사
Seroepidemiological Survey on Natural Epidemic Areas of Hemorrha gic Fever with Renal Syndrome in Linzhi Areas of Tibet
  • 万方数据
    中国媒介生物学及控制杂志 중국매개생물학급공제잡지
    CHINESE JOURNAL OF VECTOR BIOLOGY AND CONTROL
    2001年 2期 89-93 ,共5页

    陈化新%谢世宏%李书岐%罗成旺%唐浏英%余陶%唐青%张佳珂%格桑卓玛%斯塔%茶果%嘎路%索郎平措%丹巴仁增%王洪举%尼玛次仁%郁晓峰%卢效信%阎申义%次仁旺堆

    진화신%사세굉%리서기%라성왕%당류영%여도%당청%장가가%격상탁마%사탑%다과%알로%색랑평조%단파인증%왕홍거%니마차인%욱효봉%로효신%염신의%차인왕퇴

    肾综合征出血热%自然疫源地%血清流行病学调查 腎綜閤徵齣血熱%自然疫源地%血清流行病學調查
    신종합정출혈열%자연역원지%혈청류행병학조사
    Hemorrhagic fever with renal syndrome%Natural epidemic areas%Seroepidemiological survey
    目的：查明西藏林芝地区是否存在肾综合征出血热(HFRS)自然疫源地。方法：选择有疫情报告地区，进行人间疫情调查；健康人群特异性抗体检测；在山地针、阔叶混合林及山间平原的农田和居民区，用夹夜法调查小兽数量；采集捕获动物肺、血和牛、羊血清标本，检测汉坦病毒感染情况。血标本用金标免疫斑点渗滤试验和间接免疫荧光法检测抗体；动物肺的冷冻切片用免疫荧光法检测汉坦病毒抗原。结果：在西藏自治区卫生防疫站疫情资料中，有该病记载的1976年工布江达县1例，1980年林芝县9例；检测林芝地区医院住院者18人、西藏高考学生357人和其他体检人员117人血标本，仅从2名林芝县、2名工布江达县、1名察隅县的高考学生和1名住院产妇中检出抗汉坦病毒总抗体和IgG荧光抗体，被检人群隐性感染率为1.22%。检测中华姬鼠等脊椎动物肺115只，汉坦病毒抗原阳性的中华姬鼠1只，带病毒率0.87%；动物血抗汉坦病毒总抗体和IgG荧光抗体皆阳性的有中华姬鼠5只、高山田鼠1只,抗体阳性率为5.22%；检测牛、羊310只血清，其中黄牛抗汉坦病毒总抗体阳性率0.85%(1/118)，绵羊总抗体和IgG抗体阳性率1.68%(3/179)。结论：西藏林芝地区有HFRS散发病例，健康人群、中华姬鼠、高山田鼠、黄牛和绵羊中有汉坦病毒感染，证实了林芝县山地针、阔叶混合林及山间平原地带和工布江达县境域内存在着HFRS自然疫源地。
    목적：사명서장림지지구시부존재신종합정출혈열(HFRS)자연역원지。방법：선택유역정보고지구，진행인간역정조사；건강인군특이성항체검측；재산지침、활협혼합림급산간평원적농전화거민구，용협야법조사소수수량；채집포획동물폐、혈화우、양혈청표본，검측한탄병독감염정황。혈표본용금표면역반점삼려시험화간접면역형광법검측항체；동물폐적냉동절편용면역형광법검측한탄병독항원。결과：재서장자치구위생방역참역정자료중，유해병기재적1976년공포강체현1례，1980년림지현9례；검측림지지구의원주원자18인、서장고고학생357인화기타체검인원117인혈표본，부종2명림지현、2명공포강체현、1명찰우현적고고학생화1명주원산부중검출항한탄병독총항체화IgG형광항체，피검인군은성감염솔위1.22%。검측중화희서등척추동물폐115지，한탄병독항원양성적중화희서1지，대병독솔0.87%；동물혈항한탄병독총항체화IgG형광항체개양성적유중화희서5지、고산전서1지,항체양성솔위5.22%；검측우、양310지혈청，기중황우항한탄병독총항체양성솔0.85%(1/118)，면양총항체화IgG항체양성솔1.68%(3/179)。결론：서장림지지구유HFRS산발병례，건강인군、중화희서、고산전서、황우화면양중유한탄병독감염，증실료림지현산지침、활협혼합림급산간평원지대화공포강체현경역내존재착HFRS자연역원지。
    Objective：To identify if natural epidemic areas of He morrhagicFever with Renal Syndrome 〔i. e. Epidemic Hemorrhagic Fever，EHF〕 ex it in Linzhi areas of Tibet. Method：Human epidemic situat ion investigations were selected in reported areas of HFRS; Specific antibodies were detected of health population; The number of small animals were studied in forest region, in plain farms and residential areas; Hantan virus (HV) infection were detected of blood and lung samples in captured animals and blood samples of cattle and sheep, antigens of Hantan virus were detected in lung slic e with Immune Fluorescence (IF); Antibodies of HV were detected in blood s amples with gold standard immune blot and indirect-IF. Results： 1 case of HFRS was reported in Gongbujiangda co unty in 1976,9 cases in Linzhi county in 1980; 18 hospitalized patients, 357 hig h school students and other 117 physical detected persons were examined, only 2 students of Linzhi county, 2 students of Gongbujiangda,1 student of Chayu county and 1 maternity were identified positive of HV antibody and antibody IgG, the recessive infection rate was 1.22%; 1 positive of 115 detected Apodemus dr aco, the virus carrying rate was 0.87%; 5 Apodemus draco, 1 Alticola argentayus positive of total antibody and IgG, positive rate of antibody was 5.22%. The positive rate of total antibodies and IgG in cattle against HV wa s 0.85%(1/118) and sheep against HV was 1.68%(3/179) of all 310 detected blood samples. Conclusion： The fact that rare cases existed in Linzhi area of Tibet, HV infection occurred in health popu lation, Apodemus draco and Alticola argentayus. There existed the HFRS natural ep idemic areas in forest and plain farms of Linzhi areas.
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