CAJ | 학술논문

目的了解脂代谢紊乱对2型糖尿病(T2DM)患者早期胰岛素分泌功能的影响.方法 93例未经调脂和降糖治疗的新诊T2DM患者根据血脂水平分为正常血脂组(B组)、单纯TG升高组(C组)和混合血脂升高组(D组),20例体检正常者为健康对照组(A组),根据OGTT结果计算和分析早期胰岛素分泌指数△I30/△G30和HOMA-IR.结果各组之间△I30/△G30比较:B、C、D组与A组之间差异有统计学意义(P＜0.01,P＜0.05和P＜0.05),C、D组与B组之间差异有统计学意义(P＜0.05),C组与D组之间差异无统计学意义(P＞0.05);各组之间HOMA-IR比较:B、C、D组与A组之间差异有统计学意义(P＜0.05),D组与B组之间差异有统计学意义(P＜0.01),C组与B组之间差异无统计学意义(P＞0.05).结论 T2DM患者同时存在早期胰岛素分泌缺陷和胰岛素抵抗(IR),血脂异常与早期胰岛素分泌功能降低和IR相关.
목적 료해지대사문란대2형당뇨병(T2DM)환자조기이도소분비공능적영향.방법 93례미경조지화강당치료적신진T2DM환자근거혈지수평분위정상혈지조(B조)、단순TG승고조(C조)화혼합혈지승고조(D조),20례체검정상자위건강대조조(A조),근거OGTT결과계산화분석조기이도소분비지수△I30/△G30화HOMA-IR.결과 각조지간△I30/△G30비교:B、C、D조여A조지간차이유통계학의의(P＜0.01,P＜0.05화P＜0.05),C、D조여B조지간차이유통계학의의(P＜0.05),C조여D조지간차이무통계학의의(P＞0.05);각조지간HOMA-IR비교:B、C、D조여A조지간차이유통계학의의(P＜0.05),D조여B조지간차이유통계학의의(P＜0.01),C조여B조지간차이무통계학의의(P＞0.05).결론 T2DM환자동시존재조기이도소분비결함화이도소저항(IR),혈지이상여조기이도소분비공능강저화IR상관.
Objective To investigate the effects of dyslipidemia on early insulin secretion in patients with type 2 diabetes mellitus(T2DM). Methods 93 newly diagnosed T2DM patients without lipid-lowering and anti-hyperglycemic therapies were divided into 3 groups: normal lipids (group B),single high triglyceride (group C), and high triglyceride and high total cholesterol with or without low HDL-cholesterol or high LDL-cholesterol (group D).The 20 non-diabetic subjects with normal lipids were healthy control group(group A). Early insulin secretion indexes(ΔI30/ΔG30) and insulin resistance indexes(HOMA-IR) were calculated from oral glucose tolerance test. Results Compared with group A,group B,C and D had a significantly lower ΔI30/ΔG30(P<0.01,<0.05 and<0.05)and a higher HOMA-IR(all P<0.05).In contrast to group B,the group C and D had a significantly lower ΔI30/ΔG30(both P<0.05),and the group D had a significantly higher HOMA-IR(P<0.01) in T2DM groups. But no significant differences in the ΔI30/ΔG30 between group C and D,and in HOMA-IR between group B and C(both P>0.05)were observed. Conclusions High triglyceride reduces early insulin secretion function and cholesterol abnormalities increase insulin resistance in T2DM