国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2010年
5期
450-453
,共4页
小胶质细胞%星形胶质细胞%促炎症细胞因子%神经性疼痛
小膠質細胞%星形膠質細胞%促炎癥細胞因子%神經性疼痛
소효질세포%성형효질세포%촉염증세포인자%신경성동통
Microglia%Astrocyte%Proinfammatory cytokines%Neuropathic pain
正常情况下脊髓胶质细胞对疼痛不产生任何影响.但激活的胶质细胞及其释放的促炎症物质,特别是促炎症细胞因子有增强疼痛效应.然而胶质细胞如何被激活是一个关键问题,神经元-胶质细胞间信号分子可能在这方面具有重要作用.
正常情況下脊髓膠質細胞對疼痛不產生任何影響.但激活的膠質細胞及其釋放的促炎癥物質,特彆是促炎癥細胞因子有增彊疼痛效應.然而膠質細胞如何被激活是一箇關鍵問題,神經元-膠質細胞間信號分子可能在這方麵具有重要作用.
정상정황하척수효질세포대동통불산생임하영향.단격활적효질세포급기석방적촉염증물질,특별시촉염증세포인자유증강동통효응.연이효질세포여하피격활시일개관건문제,신경원-효질세포간신호분자가능재저방면구유중요작용.
Normally, spinal cord gliocytes do not have any effect on pain, but activated gliocytes and proinflammatory substances released by activated gliocytes (especially proinflammatory cytokines) have increased effects on pain. Therefore it is essential to understand how gliocytes are activated. Neuron-to-gliocyte signaling molecules may play important roles in this aspect.
