CAJ | 학술논문

近年来,血红素加氧酶-1(heme oxygenase-1,HO-1)已经成为危重病及其他许多领域的研究热点.HO-1通过分解血红素而产生的一氧化碳,胆绿素和胆红素,及亚铁离子可以减轻炎性介质反应,拮抗细胞氧化性损伤和细胞应激从而发挥细胞保护性作用.而在对重症胰腺炎(severe acute pancreatitis,SAP)的研究中,人们已经认识到拮抗炎症因子的过度释放是提高胰腺炎疗效的重要环节.本文就HO-1及其与SAP之间关系的研究进展做一综述.
근년래,혈홍소가양매-1(heme oxygenase-1,HO-1)이경성위위중병급기타허다영역적연구열점.HO-1통과분해혈홍소이산생적일양화탄,담록소화담홍소,급아철리자가이감경염성개질반응,길항세포양화성손상화세포응격종이발휘세포보호성작용.이재대중증이선염(severe acute pancreatitis,SAP)적연구중,인문이경인식도길항염증인자적과도석방시제고이선염료효적중요배절.본문취HO-1급기여SAP지간관계적연구진전주일종술.
Recently, heme oxygenase-1 (HO-1) has been emphasized in the area of intensive care unit (ICU) and other domains. HO-1 can catalyze the decomposition of heine and the products of its enzymatic activity, including carbon monoxide, biliverdin, and bilirubin and ferritin can play a significant cytoprotec-tive role in antagonizing inflammation, protecting cells from oxidative injury and cellular stresses. In the re-search of severe acute pancreatitis (SAP), researchers have realized that it is of great importance to antago-nize the overflow of cytokines in order to improve the therapeutic effect of SAP. In this article, we give a re-view of the research progress of HO-1 and its relationship with SAP.