CAJ | 학술논문

目的探讨新生儿肺炎克雷伯菌脓毒血症的耐药特性,为药物治疗提供新依据.方法对本院近五年确诊新生儿肺炎克雷伯菌脓毒血症临床病例及药敏结果进行回顾性分析.结果 50例肺炎克雷伯菌脓毒血症多为医院内感染,其中检出产ESBLs菌株13株(占26%),非产ESBLs菌株37株(占74%),均为多重耐药菌株,药敏试验证明:对常用广谱β-内酰胺类抗生素均有超强耐药;但对亚胺培南及阿米卡星等药敏感,敏感率高达100%.结论亚胺培南和阿米卡星均可作为新生儿肺炎克雷伯菌感染首选治疗药物.
목적 탐토신생인폐염극뢰백균농독혈증적내약특성,위약물치료제공신의거.방법 대본원근오년학진신생인폐염극뢰백균농독혈증림상병례급약민결과진행회고성분석.결과 50례폐염극뢰백균농독혈증다위의원내감염,기중검출산ESBLs균주13주(점26%),비산ESBLs균주37주(점74%),균위다중내약균주,약민시험증명:대상용엄보β-내선알류항생소균유초강내약;단대아알배남급아미잡성등약민감,민감솔고체100%.결론 아알배남화아미잡성균가작위신생인폐염극뢰백균감염수선치료약물.
Objective To study the drug resistance of neonatal sepsis caused by Klebsiella pneumoniae and provide evidence for drug treatment. Method Retrospectively analysis was conducted on the clinical data and antibiotic resistance of Klebsiella pneumoniae in 50 neonates with sepsis. Results The majority of the 50 cases were infected in hospital. There were 13 ESBLs strains in 50 Klebsiella pneumoniae strains (26%), and the others were negative ESBLs starins (74%). All the strains were multidrug-resistance to the β-lactam antibiotics and only sensitive to few antibiotics such as Imipenem and Amikacin. The sensitive rate was 100%. Conclusions The first selected antibiotic for the treatment of neonatal sepsis caused by Klebsiella pnemoniae was Imipenem or Amikacin.