CAJ | 학술논문

目的研究老年肾移植受者贫血的特征及其危险因素.方法回顾性分析168例首次肾移植的老年肾移植受者的临床资料,采用多因素Logistic回归方法筛选老年肾移植受者发生贫血的危险因素.结果 168例老年首次肾移植受者,贫血的总发生率为45.2％( 76/168).40例为正细胞正色素性贫血；26例为小细胞低色素性贫血；10例为溶血性贫血.76例贫血受者中,51例为红细胞生成素(EPO)缺乏；25例为EPO抵抗.贫血受者营养不良,心、脑血管病变的发生率显著高于非贫血受者(P＜0.01).环孢素、硫唑嘌呤、泼尼松方案( CsA+Aza+Pred)贫血发生率为57.1％,显著高于其他方案(P＜0.01).多因素非条件Logistic回归分析表明,男性、肌酐水平、急性排斥反应、移植肾功能延迟恢复(DGF)是老年肾移植受者贫血发生的独立危险因素,OR值分别为1.089、5.156、6.345、1.876.结论贫血是老年肾移植受者严重并发症.男性、肌酐水平、急性排斥反应、DGF是老年肾移植受者贫血发生的独立危险因素.
목적 연구노년신이식수자빈혈적특정급기위험인소.방법 회고성분석168례수차신이식적노년신이식수자적림상자료,채용다인소Logistic회귀방법사선노년신이식수자발생빈혈적위험인소.결과 168례노년수차신이식수자,빈혈적총발생솔위45.2％( 76/168).40례위정세포정색소성빈혈；26례위소세포저색소성빈혈；10례위용혈성빈혈.76례빈혈수자중,51례위홍세포생성소(EPO)결핍；25례위EPO저항.빈혈수자영양불량,심、뇌혈관병변적발생솔현저고우비빈혈수자(P＜0.01).배포소、류서표령、발니송방안( CsA+Aza+Pred)빈혈발생솔위57.1％,현저고우기타방안(P＜0.01).다인소비조건Logistic회귀분석표명,남성、기항수평、급성배척반응、이식신공능연지회복(DGF)시노년신이식수자빈혈발생적독립위험인소,OR치분별위1.089、5.156、6.345、1.876.결론 빈혈시노년신이식수자엄중병발증.남성、기항수평、급성배척반응、DGF시노년신이식수자빈혈발생적독립위험인소.
Objective To investigate the characteristics and risk factors of anemia in renal transplant recipients over 60 years old.Methods Clinical data of one hundred and sixty-eight renal transplant recipients over 60 years old were retrospectively analyzed.Logistic regression analysis was used to determine the risk factors of anemia.Results In 168 cases of renal transplant recipients,the incidence of anemia was 45.2％(76/168).Forty cases were normocyte and normochromic,26 cases were microcytic hypochromic,10 cases were hemolytic anemia.In these anemic recipients,51 cases were short of erythropoietin (EPO),25 were EPO resistance.The incidence of malnutrition and cardia-cerebrovascular complication was higher in recipients with anemia than those without anemia (P＜0.01).The incidence of anemia in CsA+Aza+Pred treatment was 57.1％,which was significantly higher as compared to other three treatments (P＜0.01).Unconditional multivariate Logistic regression analysis revealed that male,creatinine level,acute reject reaction,delayed graft function (DGF) were the independent predictors of anemia,the corresponding OR values were 1.089,5.156,6.345,1.876.Conclusions Anemia is a common and serious complication in renal transplant recipients over 60 years old.Male,creatinine level,acute reject reaction,DGF are the independent risk factors of anemia in renal transplant recipients over 60 years old.