CAJ | 학술논문

内质网是蛋白质折叠和组装的场所,各种损伤性因素均可导致内质网中未折叠蛋白的蓄积,引发以未折叠蛋白反应为主要机制的内质网应激,对细胞进行保护或启动细胞凋亡.PERK是一条内质网应激的主要信号转导通路,参与年龄相关性黄斑变性、糖尿病视网膜病变、青光眼等多种眼科疾病的发生.了解PERK通路在眼科疾病中的作用可以为眼科疾病治疗提供新的思路.
내질망시단백질절첩화조장적장소,각충손상성인소균가도치내질망중미절첩단백적축적,인발이미절첩단백반응위주요궤제적내질망응격,대세포진행보호혹계동세포조망.PERK시일조내질망응격적주요신호전도통로,삼여년령상관성황반변성、당뇨병시망막병변、청광안등다충안과질병적발생.료해PERK통로재안과질병중적작용가이위안과질병치료제공신적사로.
Endoplasmic reticulum is the organelle where proteins get folded and assembled,and all kinds of damage factors can lead to the accumulation of unfolded proteins,therefore initiate endoplasmic reticulum stress(ERS) by activating the intracellular signal transduction pathways-cumulatively called the unfolded protein response,either to protect cells or to induce cell apoptosis,PERK pathway has been considered as a main signal transduction pathway of ERS,and a lot of eye diseases are correlated with PERK pathway mediated ERS.This article mainly summarize the progress of the eye diseases associated with PERK pathway mediated ERS.