CAJ | 학술논문

目的检测巨噬细胞移动抑制因子(MIF)蛋白标记的食管鳞状细胞癌(鳞癌)组织中的微血管密度(MVD),分析MVD与临床病理的相关性.方法用免疫组织化学的方法检测MIF蛋白在40例食管鳞癌组织微血管内皮细胞中的表达,计算MVD平均值并分析其与食管鳞癌临床病理的相关性.结果 MIF蛋白在食管鳞癌组织微血管内皮细胞中的表达率为95.00%(38/40),与正常食管组织相比较[32.50%(13/40)],两者差异有统计学意义(P＜0.05).食管鳞癌组织MVD平均值为26.5±8.5,MVD与肿瘤的TNM分期、有无区域淋巴结转移密切相关(P＜0.01).结论 MIF可以作为食管鳞癌组织微血管内皮细胞的标志物之一,MVD与肿瘤的TNM分期、有无区域淋巴结转移密切相关,有可能成为预测食管鳞癌患者预后的主要因素之一.
목적 검측거서세포이동억제인자(MIF)단백표기적식관린상세포암(린암)조직중적미혈관밀도(MVD),분석MVD여림상병리적상관성.방법 용면역조직화학적방법검측MIF단백재40례식관린암조직미혈관내피세포중적표체,계산MVD평균치병분석기여식관린암림상병리적상관성.결과 MIF단백재식관린암조직미혈관내피세포중적표체솔위95.00%(38/40),여정상식관조직상비교[32.50%(13/40)],량자차이유통계학의의(P＜0.05).식관린암조직MVD평균치위26.5±8.5,MVD여종류적TNM분기、유무구역림파결전이밀절상관(P＜0.01).결론 MIF가이작위식관린암조직미혈관내피세포적표지물지일,MVD여종류적TNM분기、유무구역림파결전이밀절상관,유가능성위예측식관린암환자예후적주요인소지일.
Objective To detect the microvessel density(MVD) marked by MIF protein in esophagus squamous cell carcinoma(ESCC), and to see if a relationship exists between microvessel density(MVD) and clinicopathologic features. Methods The expression of MIF in vascular endothelial cell in forty ESCC specimens was examined by immunohistocbemistry staining, calculated the mean of MVD and analysed the relationship with clinicopathologic features. Results The positive rate of MIF protein was 95.00 %(38/40) in ESCC vascular endothelial cell. Compared with the normal esophageal squamous tissue[32.50 %(13/40)], there was significant difference in statistics, the mean of MVD was 26.5±8.5. MVD was positively correlated with the tumor TNM stages and lymph node motastasis. Conclusion MIF can be used in tagging vascular endothelial cell, MVD of ESCC was positively correlated with the tumor TNM stages and lymph node metastasis. It might be an major prognostic factor in ESCC.