CAJ | 학술논문

目的:对含聚乙二醇的两亲性聚合物种类、合成及在药物载体领域的应用进行综述.资料来源:应用计算机检索SCI-Expanded、EI Compendex和中国期刊全文数据库2000-01/2009-07关于含聚乙二醇的两亲性共聚物分类、合成及其胶束在药物载体领域研究的相关文献.资料选择:初检得到616篇文献,阅读标题和摘要进行初筛,以含聚乙二醇的两亲性共聚物的分类与合成是否全面细致,对于自主装形成胶束的影响因素是否有相当的代表性及前沿性为纳入标准,共保留31篇中英文文献进行进一步分析.结局评价指标:含聚乙二醇的两亲性共聚物分类、合成、载药机制:共聚物胶束在药物载体领域中的应用情况.结果:①星型共聚物能提高胶束稳定性,但臂数太多,有可能导致载药量降低.②共聚物中引入特定的基团有利于药物与载体的结合;连接靶向基团能使体系提供靶向运送特性.③共聚物中聚乙二醇链的长度和密度与胶束化性能有关,改变聚乙二醇长度和密度可以获得较长时间在体内循环的聚合物胶束.结论:含聚乙二醇的两亲性共聚物在医学载药领域和分离技术方面具有优越的应用潜力.
목적:대함취을이순적량친성취합물충류、합성급재약물재체영역적응용진행종술.자료래원:응용계산궤검색SCI-Expanded、EI Compendex화중국기간전문수거고2000-01/2009-07관우함취을이순적량친성공취물분류、합성급기효속재약물재체영역연구적상관문헌.자료선택:초검득도616편문헌,열독표제화적요진행초사,이함취을이순적량친성공취물적분류여합성시부전면세치,대우자주장형성효속적영향인소시부유상당적대표성급전연성위납입표준,공보류31편중영문문헌진행진일보분석.결국평개지표:함취을이순적량친성공취물분류、합성、재약궤제:공취물효속재약물재체영역중적응용정황.결과:①성형공취물능제고효속은정성,단비수태다,유가능도치재약량강저.②공취물중인입특정적기단유리우약물여재체적결합;련접파향기단능사체계제공파향운송특성.③공취물중취을이순련적장도화밀도여효속화성능유관,개변취을이순장도화밀도가이획득교장시간재체내순배적취합물효속.결론:함취을이순적량친성공취물재의학재약영역화분리기술방면구유우월적응용잠력.
OBJECTIVE: To review classification and synthesis of amphiphilic polymers containing polyethylene glycol and the application as drug carriers.DATA SOURCE: A computer-based research was conducted in SCI-Expanded, El Compendex and China Journal Full-text Database for articles concerning classification and synthesis of amphiphilic polymers containing polyethylene glycol and their micelles application as drug carriers published from January 2000 to July 2009.DATA SELECTION: A total of 616 articles were primarily obtained. Following reading titles and abstract, articles addressing detail classification and synthesis of amphiphilic polymers containing polyethylene glycol and representative micellar influencing factor were included. Totally 31 English and Chinese literatures were collected for further analysis.MAIN OUTCOME MEASURES: Classification, synthesis and drug vector mechanism of amphiphilic polymers containing polyethylene glycol and the micellar application as drug carriers were measured.RESULTS: Star-shaped copolymer could elevate micellar stability, but there were many arm numbers, whicti might induced a decrease in drug carrier volume. Special group introduced in copolymer contributed to the combination of drug and carrier. To connect target group could provide target transport property. The length and density of polyethylene glycol chain in copolymer was related to micellar function. Changed the length and density of polyethylene glycol could obtain polymer micelles that circulated in vivo for a long time.CONCLUSION: Amphiphilic polymers containing polyethylene glycol has outstanding potential in medical drug carrier field and isolation technique.