CAJ | 학술논문

为研究哮喘的易感基因,科学家们发现了一个新的基因家族--Tim基因家族,而生物信息学研究发现人Tin1就是人甲型肝炎病毒细胞受体(huHAVcr-1),另外,流行病学调查结果显示甲型肝炎病毒(HAV)感染下降与哮喘发病上升这一反转现象.此文就HAV感染对哮喘的影响,以及HAV-Tim1途径对T细胞分化的作用等方面研究进展进行综述.
위연구효천적역감기인,과학가문발현료일개신적기인가족--Tim기인가족,이생물신식학연구발현인Tin1취시인갑형간염병독세포수체(huHAVcr-1),령외,류행병학조사결과현시갑형간염병독(HAV)감염하강여효천발병상승저일반전현상.차문취HAV감염대효천적영향,이급HAV-Tim1도경대T세포분화적작용등방면연구진전진행종술.
The search for susceptible gene of asthma has led to the identification of a novel T cell immunoglobulin domain, mucin-like domain (Tim) gene family, and human Timl was initially identified as the cellular receptor for hepatitis A virus(huHAVcr-1) . This is intriguing, as several epidemiological studies have noted that infection with hepatitis A virus is associated with protection against the development of asthma in human. The influence of HAV infection to asthma and the effect of HAV-Tim in T cell differentiation are reviewed in this article.