CAJ | 학술논문

目的探讨肝移植受者围手术期甲状腺激素水平对预后的影响.方法采用放射免疫法检测82例原位肝移植受者和20例健康对照者血清中总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)以及促甲状腺激素(TSH)的水平;观察受者术后肝功能和存活情况,并分析甲状腺素水平的变化对肝功能和死亡率的影响.结果肝移植受者术前TT3和TT4水平明显低于健康对照者,且受者的甲状腺激素水平随肝功能水平降低而显著下降.术后2周内有72例受者甲状腺激素水平恢复正常,其中7例死亡,死亡率为9.7%;有10例甲状腺激素水平未恢复正常,其中5例死亡,死亡率为50%,两组死亡率的比较.差异有统计学意义(P<0.05).结论肝移植术前甲状腺激素水平的降低与肝功能损害程度呈正相关;甲状腺激素水平可作为判断肝移植预后的指标.
목적 탐토간이식수자위수술기갑상선격소수평대예후적영향.방법 채용방사면역법검측82례원위간이식수자화20례건강대조자혈청중총삼전갑상선원안산(TT3)、총갑상선소(TT4)이급촉갑상선격소(TSH)적수평;관찰수자술후간공능화존활정황,병분석갑상선소수평적변화대간공능화사망솔적영향.결과 간이식수자술전TT3화TT4수평명현저우건강대조자,차수자적갑상선격소수평수간공능수평강저이현저하강.술후2주내유72례수자갑상선격소수평회복정상,기중7례사망,사망솔위9.7%;유10례갑상선격소수평미회복정상,기중5례사망,사망솔위50%,량조사망솔적비교.차이유통계학의의(P<0.05).결론 간이식술전갑상선격소수평적강저여간공능손해정도정정상관;갑상선격소수평가작위판단간이식예후적지표.
Objective To observe perioperative change of thyroid hormone level and evaluate its prognostic significance. Methods The concentration of thyroid hormone was detected and compared with liver function and survival in 82 patients receiving liver transplantation. Results Preoperatively, the concentration of TT3 and TT4 in patients receiving liver transplantation was significantly lower than in control group. The concentration of TT3 and TT4 was decreased significantly when liver func-tion got worse. Thyroid hormone level of 72 recipients recovered to normal, and 7 patients died among these patients with the mortality being 9.7%. Thyroid hormone level of 10 patients didn't recover and 5 died with the mortality being 50% (P<0.05). Conclusion The decrease of TT3 and TT4 levels in patients receiving liver transplantation was correlated with worse liver function, and TT3 and TT4 level could be used to predict the prognosis.