CAJ | 학술논문

目的探讨白癜风患者血清中巨噬细胞移动抑制因子(MIF)和肿瘤坏死因子α(TNF-α)水平的变化及临床意义.方法酶联免疫吸附试验和放射免疫法检测66例白癜风患者和30例健康对照血清MIF和TNF-α的表达.结果寻常型白癜风患者组和健康对照组血清MIF水平分别为(9.56±1.65) μg/L和(5.18±0.81) μg/L,TNF-α水平分别为(2.38±0.37) μg/L和(1.78±0.21) μg/L,寻常型白癜风患者组均显著高于健康对照组(P值均＜ 0.01).寻常型白癜风患者血清MIF和TNF-α水平呈正相关(r=0.89,P＜ 0.05).节段型白癜风患者组血清MIF和TNF-α水平与健康对照组比较,差异均无统计学意义(P＞0.05).进展期白癜风患者血清MIF水平显著高于稳定期(P＜0.01).结论 MIF和TNF-α可能在白癜风的发病机制中起一定作用.MIF与寻常型白癜风的活动性可能有关.
목적 탐토백전풍환자혈청중거서세포이동억제인자(MIF)화종류배사인자α(TNF-α)수평적변화급림상의의.방법 매련면역흡부시험화방사면역법검측66례백전풍환자화30례건강대조혈청MIF화TNF-α적표체.결과 심상형백전풍환자조화건강대조조혈청MIF수평분별위(9.56±1.65) μg/L화(5.18±0.81) μg/L,TNF-α수평분별위(2.38±0.37) μg/L화(1.78±0.21) μg/L,심상형백전풍환자조균현저고우건강대조조(P치균＜ 0.01).심상형백전풍환자혈청MIF화TNF-α수평정정상관(r=0.89,P＜ 0.05).절단형백전풍환자조혈청MIF화TNF-α수평여건강대조조비교,차이균무통계학의의(P＞0.05).진전기백전풍환자혈청MIF수평현저고우은정기(P＜0.01).결론 MIF화TNF-α가능재백전풍적발병궤제중기일정작용.MIF여심상형백전풍적활동성가능유관.
Objective To determine the serum levels of macrophage migration inhibition factor (MIF) and tumor necrosis factor-α (TNF-α) in patients with vitiligo,and to investigate their clinical significance.Methods The serum concentrations of MIF and TNF-α were determined by enzyme linked immunosorbent assay (ELISA) and radioimmunoassay respectively in 66 patients with vitiligo and 30 healthy controls.Results The patients with vitiligo vulgaris showed a significant higher serum level of MIF and TNF-α compared with the healthy controls ((9.56 ± 1.65) vs.(5.18 ± 0.81 ) μg/L,(2.38 ± 0.37) vs.(1.78 ± 0.21 ) μg/L,both P ＜ 0.01 ).There was a positive correlation between the serum level of MIF and TNF-α (r =0.89,P ＜ 0.05).No statistical difference was observed in the serum levels of MIF or TNF-α between the healthy controls and patients with segmental vitiligo (both P ＞ 0.05).The serum level of MIF was significantly higher in patients with progressive vitiligo than in those with stable vitiligo (P ＜ 0.01 ).Conclusions MIF and TNF-α might play a certain role in the pathogenesis of vitiligo,and MIF may be related to the activity of vitiligo vulgaris.