CAJ | 학술논문

目的探讨老年帕金森病(PD)患者血尿酸水平与认知功能的关系,并对相关因素进行分析.方法回顾性分析60例老年PD患者的病历资料,选择性别、年龄相匹配的60例健康体检者作为对照,记录性别、年龄、病程、Hoehn&Yahr分期(H-Y分期)、尿酸、简易智能量表(MMSE)评分,并进行比较和相关性分析.结果老年PD组血浆尿酸水平[(262±53)μmol/L]明显低于对照组[(332±45)μmol/L],差异有统计学意义(t=-6.724,P＜0.001).PD组男性血浆尿酸水平[(271±48)μmol/L]均值略高于女性水平[(254±39)μmol/L],但差异无统计学意义(t=3.282,P=0.058).PD组男性血浆尿酸水平明显低于对照组男性尿酸水平[(353±62)μmol/L],差异有统计学意义(t=-5.625,P＜0.001).PD组女性血浆尿酸水平低于对照组女性尿酸水平[(294±59)/μmol/L],差异有统计学意义(t=-4.721,P=0.012).老年PD各亚组间血尿酸水平无显著差异,但与对照组比较差异均有统计学意义(F=22,039,P＜0,01).老年PD组血尿酸水平与病程长短无明显相关性(r=0.961,P＞0,05).老年PD患者存在认知功能障碍,其MMSE评分与H-Y分期(r=-0.577,P=0.019)、年龄(r=-0.333,P=0.034)呈负相关,与血尿酸水平呈正相关(r=0.789,P=0.000),与病程(r=-0.333,P=0.027)、体质指数(BMI)(t=-0.410,P=0.115)无相关性.结论老年PD患者血尿酸水平降低,低尿酸水平可能与老年PD患者的认知功能障碍有关.
목적 탐토노년파금삼병(PD)환자혈뇨산수평여인지공능적관계,병대상관인소진행분석.방법 회고성분석60례노년PD환자적병력자료,선택성별、년령상필배적60례건강체검자작위대조,기록성별、년령、병정、Hoehn&Yahr분기(H-Y분기)、뇨산、간역지능량표(MMSE)평분,병진행비교화상관성분석.결과 노년PD조혈장뇨산수평[(262±53)μmol/L]명현저우대조조[(332±45)μmol/L],차이유통계학의의(t=-6.724,P＜0.001).PD조남성혈장뇨산수평[(271±48)μmol/L]균치략고우녀성수평[(254±39)μmol/L],단차이무통계학의의(t=3.282,P=0.058).PD조남성혈장뇨산수평명현저우대조조남성뇨산수평[(353±62)μmol/L],차이유통계학의의(t=-5.625,P＜0.001).PD조녀성혈장뇨산수평저우대조조녀성뇨산수평[(294±59)/μmol/L],차이유통계학의의(t=-4.721,P=0.012).노년PD각아조간혈뇨산수평무현저차이,단여대조조비교차이균유통계학의의(F=22,039,P＜0,01).노년PD조혈뇨산수평여병정장단무명현상관성(r=0.961,P＞0,05).노년PD환자존재인지공능장애,기MMSE평분여H-Y분기(r=-0.577,P=0.019)、년령(r=-0.333,P=0.034)정부상관,여혈뇨산수평정정상관(r=0.789,P=0.000),여병정(r=-0.333,P=0.027)、체질지수(BMI)(t=-0.410,P=0.115)무상관성.결론 노년PD환자혈뇨산수평강저,저뇨산수평가능여노년PD환자적인지공능장애유관.
Objective To explore the relationship between uric acid (UA) level and cognitive function in elderly patients with Parkinson,s disease (PD) and analyze the cognition related factors.Methods The clinical data of 60 elderly PD cases in our hospital from 2001 to 2009 were retrospectively analyzed. The 60 healthy people receiving medical examination in our hospital and matched by gender and age, were as control group. The information including gender, age, illness duration, Hoehn & Yahr stage (H-Y stage), serum UA level and Mini-Mental State Examination (MMSE) scale were recorded. Results The serum UA level was significantly lower in PD group than in control group [(262±53) μmol/L vs. (332±45) μmol/L, t=-6.724, P＜0.001]. In PD group, the serum UA level was slightly higher in males than in females [(271 ±48) μmol/L vs.(254±39) μmol/L, t=3. 282, P=0. 058]. The serum UA level was significantly lower in male PD patients than in male controls [(353± 62) μmol/L, t=- 5. 625, P＜0. 001], and was lower in female PD patients than in female controls [( 294 ± 59) μmol/L, t = - 4. 721, P = 0. 012]. There were no significant differences in serum UA level among different H-Y stage subgroups (P＞0. 05), but the serum UA level was lower in different H-Y stage subgroups than in control group (F=22. 039, P＜0. 01 ). There was no correlation between the UA level and the illness duration (r=0. 961, P＞0.05).The MMSE score had significant difference between elderly PD group and control group (t= -3. 168,P＜0. 001). In PD patients, the MMSE score was positively correlated with serum UA level (r=0. 789, P= 0. 000), and was negatively correlated with H-Y stage (r= - 0. 577, P = 0. 019 ), age (r= -0. 333, P=0. 034), but was not correlated with illness duration (r= -0. 333, P=0. 207) and BMI (t=- 0. 410, P= 0. 115). Conclusions The level of serum UA is lower in elderly patients with PD than in normal controls. There is correlation between the serum UA level and cognitive impairment. Lower serum UA level predicts worse cognitive scores.