CAJ | 학술논문

采用电化学发光技术对166例妊娠期肝内胆汁淤积症(ICP)患者血清促甲状腺激素(TSH)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)水平进行检测,并与正常妊娠妇女及参与筛查的妊娠妇女进行比较.结果显示,与正常妊娠妇女比较,ICP孕妇血清TSH、TPOAb明显升高,FT4水平无明显变化,其TPOAb阳性率达22.9%(38/166).ICP孕妇易合并各种甲状腺疾病,总发生率35.5%(59/166),明显高于同期筛查妊娠妇女17.1%(143/837).妊娠期ICP妇女甲状腺功能存在异常,可能参与了ICP的发生及发展.
채용전화학발광기술대166례임신기간내담즙어적증(ICP)환자혈청촉갑상선격소(TSH)、유리갑상선소(FT4)、갑상선과양화물매항체(TPOAb)수평진행검측,병여정상임신부녀급삼여사사적임신부녀진행비교.결과 현시,여정상임신부녀비교,ICP잉부혈청TSH、TPOAb명현승고,FT4수평무명현변화,기TPOAb양성솔체22.9%(38/166).ICP잉부역합병각충갑상선질병,총발생솔35.5%(59/166),명현고우동기사사임신부녀17.1%(143/837).임신기ICP부녀갑상선공능존재이상,가능삼여료ICP적발생급발전.
A total of 166 women with intrahepatic cholestasis in pregnancy (ICP) participated in the study. Serum levels of thyroid stimulating hormone (TSH), free thyroxine 4 (FT4) and thyroid peroxidase antibody (TPOAb) were quantified for all of them with electrochemiluminescence (ECL) technique, and compared with those in normal pregnant women. Results showed that serum TSH and TPOAb [22. 9%(38/166)] increased significantly, but no significant change in serum level of FT4 was observed in women with ICP, as compared to those in normal pregnant women. Overall prevalence of thyroid diseases in ICP women was 35.5% (59/166), significantly higher than that in normal population screened for thyroid disease (17. 1%, 143/837) at the same time period. It suggests that thyroid dysfunction may be involved in pathogenesis of ICP.