CAJ | 학술논문

目的探讨盐酸多奈哌齐治疗老年轻度认知功能障碍(MCI)患者的临床疗效及脑电图(EEG)、事件相关电位(ERP)P300的变化. 方法选取上海交通大学附属上海市第六人民医院老年科自2009年1月至2010年3月就诊的115例老年MCI患者,按完全随机数字表法分为盐酸多奈哌齐联合银杏叶制剂治疗组(治疗组,58例)和单用银杏叶制剂治疗组(对照组,57例),观察2组患者治疗前后简易精神状况检查量表(MMSE)评分以及EEG、P300的改变,评估临床疗效,并在组间进行比较. 结果治疗后2组患者MMSE评分均较治疗前有所提高,但治疗组提高更为明显,与治疗前和对照组比较差异均有统计学意义(P＜0.05).治疗组的EEG异常率(25.86％)明显低于对照组(45.61％),差异有统计学意义(P＜0.05).治疗后2组患者P300潜伏期均有缩短、波幅增高,但治疗组变化更为明显,与治疗前及对照组比较差异均有统计学意义(P＜0.05).秩和检验发现治疗组临床疗效明显优于对照组,差异有统计学意义(P＜0.05). 结论与单用银杏叶制剂比较,盐酸多奈哌齐联合银杏叶制剂治疗能显著改善老年MCI患者认知功能及脑电活动状态,提示盐酸多奈哌齐在老年MCI治疗中有一定价值.
목적 탐토염산다내고제치료노년경도인지공능장애(MCI)환자적림상료효급뇌전도(EEG)、사건상관전위(ERP)P300적변화. 방법 선취상해교통대학부속상해시제륙인민의원노년과자2009년1월지2010년3월취진적115례노년MCI환자,안완전수궤수자표법분위염산다내고제연합은행협제제치료조(치료조,58례)화단용은행협제제치료조(대조조,57례),관찰2조환자치료전후간역정신상황검사량표(MMSE)평분이급EEG、P300적개변,평고림상료효,병재조간진행비교. 결과 치료후2조환자MMSE평분균교치료전유소제고,단치료조제고경위명현,여치료전화대조조비교차이균유통계학의의(P＜0.05).치료조적EEG이상솔(25.86％)명현저우대조조(45.61％),차이유통계학의의(P＜0.05).치료후2조환자P300잠복기균유축단、파폭증고,단치료조변화경위명현,여치료전급대조조비교차이균유통계학의의(P＜0.05).질화검험발현치료조림상료효명현우우대조조,차이유통계학의의(P＜0.05). 결론 여단용은행협제제비교,염산다내고제연합은행협제제치료능현저개선노년MCI환자인지공능급뇌전활동상태,제시염산다내고제재노년MCI치료중유일정개치.
Objective To explore the clinical efficacy of donepezil hydrochloride in the treatment of elderly patients with mild cognitive impairment (MCI) and changes of their electroencephalogram (EEG) and event related potential (ERP) P300. Methods One hundred and fifteen patients with MCI,admitted to our hospital from January 2009 to March 2010,were randomly divided into treatment group (hydrochloride donepezil combined with ginkgo biloba,n=58) and control group (single-use ginkgo biloba,n=57).Mini-mental state examination (MMSE) scores,changes of P300 and EEG were used to assess the effect of donepezil hydrochloride. Results After 12 months of treatment,MMSE scores in both groups improved,and the MMSE scores in the treatment group were significantly higher than those in the control group or treatment group before treatment (P＜0.05). The abnormal rate of EEG in the treatment group (25.86％) was significantly lower than that in the control group (45.61％),and the difference was statistically significance (P＜0.05).The latency of P300 was decreased and the amplitude was increased in both groups,but more obvious changes were observed in the treatment group as compared with those in the control group and treatment group before treatment (P＜0.05).The clinical efficacy of treatment group was significantly better than that of control group (P＜0.05). Conclusion As compared with ginkgo biloba,donepezil can significant improve the treatment efficacy of cognitive ability in patients with MCI and the state of brain electrical activity,which indicates that donepezil is valuable in the treatment of elderly MCI.