CAJ | 학술논문

目的:寻找磷酸钙骨水泥/顺铂复合体修复肿瘤性骨缺损的最佳质量构成比.方法:通过原子吸收分光光度法对通过混合-模压法制备的不同质量比构成的磷酸钙骨水泥/顺铂复合体体外缓释液中顺铂浓度进行测定,寻找最合适的磷酸钙骨水泥、顺铂质量构成比,在此基础上制备骨缺损和移植肿瘤动物模型和动物体内进行骨缺损的修复实验和体内抑瘤实验.结果:含0.1%～0.2%顺铂的磷酸钙骨水泥能够修复兔骨缺损,同时又能对肿瘤细胞产生抑制杀伤作用.结论:含0.1%～0.2%顺铂的磷酸钙骨水泥能够消灭残存肿瘤细胞,且最终不影响骨修复的进程.
목적:심조린산개골수니/순박복합체수복종류성골결손적최가질량구성비.방법:통과원자흡수분광광도법대통과혼합-모압법제비적불동질량비구성적린산개골수니/순박복합체체외완석액중순박농도진행측정,심조최합괄적린산개골수니、순박질량구성비,재차기출상제비골결손화이식종류동물모형화동물체내진행골결손적수복실험화체내억류실험.결과:함0.1%～0.2%순박적린산개골수니능구수복토골결손,동시우능대종류세포산생억제살상작용.결론:함0.1%～0.2%순박적린산개골수니능구소멸잔존종류세포,차최종불영향골수복적진정.
Objective To explore the best mass ratio of calcium phosphate cement (CPC) / cisplatin complex filling and to repair bone defect caused by tumor resection. Methods Mixed-molding method was used to obtain cisplatin/calcium phosphate cement complex at 0, 0.1%, 0.2%, and 0.4% mass ratio. Drug concentration was determined by atomic absorption spectrophotometry. Bone defect of rabbits and osteosarcoma of rats were prepared. We implanted CPC and CPC/cisplatin complex to observe the repair of bone defect and the inhibition of tumor in vivo. Results CPC containing 0.1% ～ 0. 2 % cisplatin not only repaired the bone defect in rabbits but also eliminated osteosarcoma in rats. Conclusion CPC containing 0.1% ～ 0. 2 % cisplatin can repair bone defect and eliminate tumor without influencing the prosthetic precess.