化工进展
化工進展
화공진전
CHEMICAL INDUSTRY AND ENGINEERING PROGRESS
2010年
2期
323-327
,共5页
杨磊%李彤%张琳%路祺%祖元刚
楊磊%李彤%張琳%路祺%祖元剛
양뢰%리동%장림%로기%조원강
雷公藤%雷公藤甲素%加压提取%响应面
雷公籐%雷公籐甲素%加壓提取%響應麵
뢰공등%뢰공등갑소%가압제취%향응면
Tripterygium wilfordii Hook.f%triptolide%pressurized liquid extraction%response surface methodology
以雷公藤为原料,采用加压溶剂法提取雷公藤甲素,以1,2-二氯乙烷为溶剂,考察了提取时间、料液比和提取温度等因素对提取工艺的影响,并在单因素试验基础上,根据中心组合试验设计原理采用三因素三水平的响应面分析法进行工艺优化,得到提取过程优化的工艺条件为:料液比1:9.7,提取温度115℃,提取时间80 min,雷公藤甲素的实际得率可达0.173‰,纯度为1.21%,与常规回流提取法相比优势明显.
以雷公籐為原料,採用加壓溶劑法提取雷公籐甲素,以1,2-二氯乙烷為溶劑,攷察瞭提取時間、料液比和提取溫度等因素對提取工藝的影響,併在單因素試驗基礎上,根據中心組閤試驗設計原理採用三因素三水平的響應麵分析法進行工藝優化,得到提取過程優化的工藝條件為:料液比1:9.7,提取溫度115℃,提取時間80 min,雷公籐甲素的實際得率可達0.173‰,純度為1.21%,與常規迴流提取法相比優勢明顯.
이뢰공등위원료,채용가압용제법제취뢰공등갑소,이1,2-이록을완위용제,고찰료제취시간、료액비화제취온도등인소대제취공예적영향,병재단인소시험기출상,근거중심조합시험설계원리채용삼인소삼수평적향응면분석법진행공예우화,득도제취과정우화적공예조건위:료액비1:9.7,제취온도115℃,제취시간80 min,뢰공등갑소적실제득솔가체0.173‰,순도위1.21%,여상규회류제취법상비우세명현.
Triptolide was extracted from Tripterygium wilfordii Hook.f by pressurized liquid extraction with 1,2-dichloroethane.Main factors affecting the extraction process were discussed,and the optimum extraction conditions were obtained as: the solid to liquid ratio is 1:9.7,the extraction temperature is 115 ～C and the extraction time is 80 min.Under the optimized conditions,the actual yield and purity of triptolide were 0.173%o and 1.21% respectively.This process has obvious advantages as compared with conventional reflux extraction.
