CAJ | 학술논문

背景:睫状神经营养因子广泛分布于神经系统,具有广谱营养作用.目的:综述国内外关于睫状神经营养因子在神经损伤及修复中的地位与应用前景.方法:计算机检索中国期刊全文数据(网址http://dlib.cnki.net/kns50/index.aspx)及PubMed数据库(网址http://www.ncbi.nlm.nih.gov/pubmed/)1990-01/2009-06期间相关文章,检索词为"睫状神经营养因子,神经损伤,Ciliary neurotrophic factor,Nerve injure".纳入与神经损伤与睫状神经营养因子研究现状与发展密切相关的研究,包括神经元损伤后的变化;睫状神经营养因子对神经元的修复机制及保护作用,对修复过程的调控,对神经元轴浆运输功能的恢复,对损伤神经的再生作用.排除重复性研究或Meta分析.结果与结论:睫状神经营养因子广泛分布于神经系统,具有广谱营养作用.神经元内源性睫状神经营养因子主要来源于周围神经许旺细胞、中枢神经胶质细胞以及神经元的自分泌.在神经损伤的修复过程中,睫状神经营养因子通过不同的方式对损伤神经元进行保护和修复.睫状神经营养因子可以通过对几种相关酶的调节而促进神经损伤的恢复,能提高细胞内JAK-STAT途径促进相关蛋白和重要分子的产生,可以促进轴浆运输,使修复加快,睫状神经营养因子还可以通过加强许旺细胞的增殖和变化促进神经的修复.睫状神经营养因子在受损神经元的修复中起着很重要的作用.通过研究探索睫状神经营养因子对神经损伤治疗的作用,有利于开发应用睫状神经营养因子来治疗神经损伤.
배경:첩상신경영양인자엄범분포우신경계통,구유엄보영양작용.목적:종술국내외관우첩상신경영양인자재신경손상급수복중적지위여응용전경.방법:계산궤검색중국기간전문수거(망지http://dlib.cnki.net/kns50/index.aspx)급PubMed수거고(망지http://www.ncbi.nlm.nih.gov/pubmed/)1990-01/2009-06기간상관문장,검색사위"첩상신경영양인자,신경손상,Ciliary neurotrophic factor,Nerve injure".납입여신경손상여첩상신경영양인자연구현상여발전밀절상관적연구,포괄신경원손상후적변화;첩상신경영양인자대신경원적수복궤제급보호작용,대수복과정적조공,대신경원축장운수공능적회복,대손상신경적재생작용.배제중복성연구혹Meta분석.결과여결론:첩상신경영양인자엄범분포우신경계통,구유엄보영양작용.신경원내원성첩상신경영양인자주요래원우주위신경허왕세포、중추신경효질세포이급신경원적자분비.재신경손상적수복과정중,첩상신경영양인자통과불동적방식대손상신경원진행보호화수복.첩상신경영양인자가이통과대궤충상관매적조절이촉진신경손상적회복,능제고세포내JAK-STAT도경촉진상관단백화중요분자적산생,가이촉진축장운수,사수복가쾌,첩상신경영양인자환가이통과가강허왕세포적증식화변화촉진신경적수복.첩상신경영양인자재수손신경원적수복중기착흔중요적작용.통과연구탐색첩상신경영양인자대신경손상치료적작용,유리우개발응용첩상신경영양인자래치료신경손상.
BACKGROUND:Ciliary neurotrophic factor (CNTF) is widely distributed in neuronal system, which has nutritional function. OBJECTIVE: To summarize the position and application prospect of CNTF on neural injury and reparation in China and abroad. METHODS: Computer-based online search of Chinese Full Text Databases (website: http://dlib.cnki.net/kns50/index.aspx) and PubMed databases (website: http://www. Ncbi.nlm.nih.gov/pubmed/) was performed with key words of "Ciliary neurotrophic factor, Nerve injure" from January 1990 to June 2009. Research concerning research status and development of CNTF was selected,including changes of CNTF following nerve injury; the repair mechanism and protection of CNTF on neurons; regulation on reparative process; the recovery of axoplasmic transport function of axoplasm, as well as the regeneration on injured nerves. The repeated research or Meta analysis was excluded. RESULTS AND CONCLUSION: CNTF had trophic action and was widely distributed in nervous system. The source of endogenous CNTF was autocrine of Schwann cells, glial cells and neurons. In the repair process of nerve injury, CNTF protected and repaired the injured nerves via various ways, such as regulated related enzyme expression, boost JAK-STAT to promote production of GAP-associated protein GAP and molecular, advance axoplasmic transport and restore, and promote neural restore by enhancing Schwann corpuscular vegetation variation. CNTF plays an important role in the recovery of injured nerves. Studies regarding the effects of CNTF on neural injuries are providing a basis for its clinical application.