中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2012年
4期
255-258
,共4页
杨仪%刘增礼%唐军%洪智慧%尤嘉熙
楊儀%劉增禮%唐軍%洪智慧%尤嘉熙
양의%류증례%당군%홍지혜%우가희
肾小球滤过率%体层摄影术,发射型计算机,单光子%体层摄影术,X线计算机%肾脏深度%Tonnesen公式
腎小毬濾過率%體層攝影術,髮射型計算機,單光子%體層攝影術,X線計算機%腎髒深度%Tonnesen公式
신소구려과솔%체층섭영술,발사형계산궤,단광자%체층섭영술,X선계산궤%신장심도%Tonnesen공식
Glomerular filtration rate%Tomography,emission-computed,single-photon%Tomography,X-ray computed%Renal depth%Tonnesen formula
目的 探讨在以SPECT/CT测定GFR时用CT直接测量肾脏深度代替传统的Tonnesen公式法的必要性和可行性.方法 49例患者在接受肾动态显像的同时进行腹部CT平扫,测量两侧肾的深度.将所测值与传统的Tonnesen公式值和SPECT侧位平面图像测量值进行比较,然后将CT和SPECT测得的肾脏深度数据代入到Gates法GFR测量软件中,观察肾脏深度改变对GFR测定值的影响.采用配对t检验对Tonnesen公式法和SPECT测量法测得的肾脏深度值及各自深度值对应的GFR与CT法测得的相关数据间差异进行比较,对Tonnesen公式误差、SPECT测量误差与肾脏深度的关系采用直线相关分析.结果 CT测得的肾脏深度分别为右肾(7.04±1.15) cm,左肾(7.18±1.15) cm.与CT测量值相比,Tonnesen公式法低估了肾脏深度[右肾:(5.77±0.90) cm,t=- 11.50,P＜0.01;左肾:(5.74±0.88) cm,t=12.20,P＜0.01],而SPECT测量值则高估了肾脏深度[右肾:(7.40±1.15) cm,t=5.19,P＜0.01;左肾:(7.49±1.19) cm,=5.14,P＜0.01].Tonnesen公式法误差与肾脏深度呈正相关(右肾:r =0.62,P＜0.01;左肾:r=0.73,P＜0.01),而SPECT测量误差与肾脏深度不相关(右肾r =0.26,P＞0.05;左肾r=0.38,P＜0.01).Tonnesen公式法得到的两侧肾脏深度差为0.03 ～0.05 cm,而SPECT和CT得到两侧肾脏深度差分别为0.54±0.33(0.01～1.28) cm和0.62±0.45(0.01～1.60) cm.Gates法采用Tonnesen公式肾脏深度低估了GFR,与CT所测肾脏深度对应的GFR相比,误差百分比分别为右肾(-20.92±11.28)％(t=-6.99,P＜0.01),左肾(-23.71±7.71)％(t=-8.73,P＜0.01);采用SPECT测量则高估了GFR,对应误差百分比为右肾(5.23±9.64)％(t=2.72,P＜0.01),左肾(8.93±9.29)％(=5.21,P＜0.01).结论 采用SPECT/CT的CT功能精确测量两侧肾脏深度,有助于提高Gates法GFR测定的准确性.
目的 探討在以SPECT/CT測定GFR時用CT直接測量腎髒深度代替傳統的Tonnesen公式法的必要性和可行性.方法 49例患者在接受腎動態顯像的同時進行腹部CT平掃,測量兩側腎的深度.將所測值與傳統的Tonnesen公式值和SPECT側位平麵圖像測量值進行比較,然後將CT和SPECT測得的腎髒深度數據代入到Gates法GFR測量軟件中,觀察腎髒深度改變對GFR測定值的影響.採用配對t檢驗對Tonnesen公式法和SPECT測量法測得的腎髒深度值及各自深度值對應的GFR與CT法測得的相關數據間差異進行比較,對Tonnesen公式誤差、SPECT測量誤差與腎髒深度的關繫採用直線相關分析.結果 CT測得的腎髒深度分彆為右腎(7.04±1.15) cm,左腎(7.18±1.15) cm.與CT測量值相比,Tonnesen公式法低估瞭腎髒深度[右腎:(5.77±0.90) cm,t=- 11.50,P＜0.01;左腎:(5.74±0.88) cm,t=12.20,P＜0.01],而SPECT測量值則高估瞭腎髒深度[右腎:(7.40±1.15) cm,t=5.19,P＜0.01;左腎:(7.49±1.19) cm,=5.14,P＜0.01].Tonnesen公式法誤差與腎髒深度呈正相關(右腎:r =0.62,P＜0.01;左腎:r=0.73,P＜0.01),而SPECT測量誤差與腎髒深度不相關(右腎r =0.26,P＞0.05;左腎r=0.38,P＜0.01).Tonnesen公式法得到的兩側腎髒深度差為0.03 ～0.05 cm,而SPECT和CT得到兩側腎髒深度差分彆為0.54±0.33(0.01～1.28) cm和0.62±0.45(0.01～1.60) cm.Gates法採用Tonnesen公式腎髒深度低估瞭GFR,與CT所測腎髒深度對應的GFR相比,誤差百分比分彆為右腎(-20.92±11.28)％(t=-6.99,P＜0.01),左腎(-23.71±7.71)％(t=-8.73,P＜0.01);採用SPECT測量則高估瞭GFR,對應誤差百分比為右腎(5.23±9.64)％(t=2.72,P＜0.01),左腎(8.93±9.29)％(=5.21,P＜0.01).結論 採用SPECT/CT的CT功能精確測量兩側腎髒深度,有助于提高Gates法GFR測定的準確性.
목적 탐토재이SPECT/CT측정GFR시용CT직접측량신장심도대체전통적Tonnesen공식법적필요성화가행성.방법 49례환자재접수신동태현상적동시진행복부CT평소,측량량측신적심도.장소측치여전통적Tonnesen공식치화SPECT측위평면도상측량치진행비교,연후장CT화SPECT측득적신장심도수거대입도Gates법GFR측량연건중,관찰신장심도개변대GFR측정치적영향.채용배대t검험대Tonnesen공식법화SPECT측량법측득적신장심도치급각자심도치대응적GFR여CT법측득적상관수거간차이진행비교,대Tonnesen공식오차、SPECT측량오차여신장심도적관계채용직선상관분석.결과 CT측득적신장심도분별위우신(7.04±1.15) cm,좌신(7.18±1.15) cm.여CT측량치상비,Tonnesen공식법저고료신장심도[우신:(5.77±0.90) cm,t=- 11.50,P＜0.01;좌신:(5.74±0.88) cm,t=12.20,P＜0.01],이SPECT측량치칙고고료신장심도[우신:(7.40±1.15) cm,t=5.19,P＜0.01;좌신:(7.49±1.19) cm,=5.14,P＜0.01].Tonnesen공식법오차여신장심도정정상관(우신:r =0.62,P＜0.01;좌신:r=0.73,P＜0.01),이SPECT측량오차여신장심도불상관(우신r =0.26,P＞0.05;좌신r=0.38,P＜0.01).Tonnesen공식법득도적량측신장심도차위0.03 ～0.05 cm,이SPECT화CT득도량측신장심도차분별위0.54±0.33(0.01～1.28) cm화0.62±0.45(0.01～1.60) cm.Gates법채용Tonnesen공식신장심도저고료GFR,여CT소측신장심도대응적GFR상비,오차백분비분별위우신(-20.92±11.28)％(t=-6.99,P＜0.01),좌신(-23.71±7.71)％(t=-8.73,P＜0.01);채용SPECT측량칙고고료GFR,대응오차백분비위우신(5.23±9.64)％(t=2.72,P＜0.01),좌신(8.93±9.29)％(=5.21,P＜0.01).결론 채용SPECT/CT적CT공능정학측량량측신장심도,유조우제고Gates법GFR측정적준학성.
Objective To investigate the necessity and feasibility of renal depth measured by CT for the measurement of GFR with SPECT/CT.Methods CT and lateral planar imaging of SPECT along with dynamic 99Tcm-DTPA renal scintigraphy (DRS) was performed in 49 patients.The renal depth estimated by Tonnesen formula and SPECT was compared with that measured by CT using paired t-test.GFR was recalculated by the Gates method using the renal depth measured by CT,Tonnesen formula and SPECT.Linear correlation analysis was used between the renal depth by CT and measurement error caused by Tonnesen formula and lateral planar imaging of SPECT.Paired t-test was also performed with software SPSS 15.0.Results Compared with CT,the renal depth was substantially underestimated by Tonnesen formula ( right kidney:(5.77±0.90) cm,t=-11.50,P＜0.01; left kidney:(5.74±0.88) cm,t =12.20,P＜0.01),which resulted in the underestimation of GFR (right kidney:( -20.92 ± 11.28)％,t =-6.99,P＜0.01 ;left kidney:( -23.71 ±7.71 )％,t =-8.73,P ＜0.01 ) ; while,it was overestimated by SPECT ( right kidney:(7.40 ± 1.15) cm,t =5.19,P ＜0.01 ; left kidney (7.49 ± 1.19) cm,t =5.14,P ＜0.01 ),which resulted in the overestimation of GFR ( right kidney:( 5.23 ± 9.64 ) ％,t =2.72,P ＜ 0.01 ; left kidney:(8.93 ±9.29) ％,t =5.21,P ＜0.01 ).The error for the calculation of renal depth by Tonnesen formula was positively correlated with the true value (right kidney r =0.62,P ＜0.01 ; left kidney r =0.73,P ＜ 0.01 ).However,there was no correlation between the error of the renal depth measured by SPECT and the true value (right kidney:r =0.26,P ＞0.05; left kidney:r =0.38,P ＜0.01 ).Conclusion SPECT/CT can improve the accuracy of GFR measurement by the Gates method using renal depth measured by CT.
