CAJ | 학술논문

回顾性分析330例确诊原发性醛固酮增多症(PA)患者的临床资料。结果显示，330例PA患者均有高血压，其中3.64％的患者为1级高血压，20.91％为2级，75.45％为3级；PA患者青中年的比例为89.09％，超重肥胖者的比例为81.82％，与正常体重的PA患者相比，超重肥胖者中男性明显多于女性(P＜0.01)；低钾血症发生率32.12％，偏相关分析显示血钾水平与病程无相关。logistic回归分析显示醛固酮水平是PA患者发生低血钾的独立危险因素(P＜0.01)。79.09％的患者血浆醛固酮水平＞12 ng/dl且肾素活性＜1 ng·ml-1 h-1，而94.24％的患者醛固酮肾素活性比值＞20。
회고성분석330례학진원발성철고동증다증(PA)환자적림상자료。결과현시，330례PA환자균유고혈압，기중3.64％적환자위1급고혈압，20.91％위2급，75.45％위3급；PA환자청중년적비례위89.09％，초중비반자적비례위81.82％，여정상체중적PA환자상비，초중비반자중남성명현다우녀성(P＜0.01)；저갑혈증발생솔32.12％，편상관분석현시혈갑수평여병정무상관。logistic회귀분석현시철고동수평시PA환자발생저혈갑적독립위험인소(P＜0.01)。79.09％적환자혈장철고동수평＞12 ng/dl차신소활성＜1 ng·ml-1 h-1，이94.24％적환자철고동신소활성비치＞20。
The clinical data of 330 patients with primary aldosteronism (PA) from January 2006 to March 2010 were retrospectively analyzed. The prevalence of 1, 2, and 3 stage hypertension in these subjects was 3.64％,20. 91％, and 75.45 ％, respectively. Of all PA patients, 89.09％ were young adults and 81.82％ were overweight or obese. There was a marked preponderance of male patients in the overweight or obese group ( P＜0. 01 ). The incidence of hypokalemia was 32. 12％. The concentration of serum potassium was not associated with the disease course. Logistic regression showed that the concentration of plasma aldosterone was an independent risk factor of hypokalemia in PA patients( P＜0. 01 ). 79. 09％ PA patients presented the plasma aldosterone level over 12 ng/dl and the renin activity level of less than 1 ng · ml-1 · h-1. The aldosterone-to-rennin activity ratio was ＞20 in 94.24％ of the patients with PA.