中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2012年
9期
936-938
,共3页
简易精神状态量表%蒙特利尔认知评估量表%轻度认知障碍%盐酸多奈哌齐
簡易精神狀態量錶%矇特利爾認知評估量錶%輕度認知障礙%鹽痠多奈哌齊
간역정신상태량표%몽특리이인지평고량표%경도인지장애%염산다내고제
Mini Mental State Examination%Montreal Cognitive Assessment%Mild cognitive impairment%Donepezil hydrochloride
目的 探讨盐酸多奈哌齐对轻度认知障碍(MCI)患者蒙特利尔认知评估量表(MoCA)评分和认知功能的影响. 方法 哈尔滨医科大学附属第一医院神经内科自2010年9月至2011年3月共收治MCI患者50例,其中给予盐酸多奈哌齐治疗30例(盐酸多奈哌齐组),银杏叶片治疗20例(对照组),分析并比较2组患者治疗前、治疗12周、24周后MoCA评分的变化. 结果 盐酸多奈哌齐组患者治疗12、24周时MoCA评分高于治疗前,差异有统计学意义(P＜0.05).治疗12周、24周时盐酸多奈哌齐组MoCA评分均高于对照组,差异有统计学意义(P＜0.05);治疗12周时盐酸多奈哌齐组患者在数字广度、词语流畅性和延迟记忆方面的分项得分高于治疗前,差异有统计学意义(P＜0.05). 结论 MoCA量表能够对MCI患者进行早期诊断,盐酸多奈哌齐对MCI患者进行早期治疗能延缓其进入AD的病程.
目的 探討鹽痠多奈哌齊對輕度認知障礙(MCI)患者矇特利爾認知評估量錶(MoCA)評分和認知功能的影響. 方法 哈爾濱醫科大學附屬第一醫院神經內科自2010年9月至2011年3月共收治MCI患者50例,其中給予鹽痠多奈哌齊治療30例(鹽痠多奈哌齊組),銀杏葉片治療20例(對照組),分析併比較2組患者治療前、治療12週、24週後MoCA評分的變化. 結果 鹽痠多奈哌齊組患者治療12、24週時MoCA評分高于治療前,差異有統計學意義(P＜0.05).治療12週、24週時鹽痠多奈哌齊組MoCA評分均高于對照組,差異有統計學意義(P＜0.05);治療12週時鹽痠多奈哌齊組患者在數字廣度、詞語流暢性和延遲記憶方麵的分項得分高于治療前,差異有統計學意義(P＜0.05). 結論 MoCA量錶能夠對MCI患者進行早期診斷,鹽痠多奈哌齊對MCI患者進行早期治療能延緩其進入AD的病程.
목적 탐토염산다내고제대경도인지장애(MCI)환자몽특리이인지평고량표(MoCA)평분화인지공능적영향. 방법 합이빈의과대학부속제일의원신경내과자2010년9월지2011년3월공수치MCI환자50례,기중급여염산다내고제치료30례(염산다내고제조),은행협편치료20례(대조조),분석병비교2조환자치료전、치료12주、24주후MoCA평분적변화. 결과 염산다내고제조환자치료12、24주시MoCA평분고우치료전,차이유통계학의의(P＜0.05).치료12주、24주시염산다내고제조MoCA평분균고우대조조,차이유통계학의의(P＜0.05);치료12주시염산다내고제조환자재수자엄도、사어류창성화연지기억방면적분항득분고우치료전,차이유통계학의의(P＜0.05). 결론 MoCA량표능구대MCI환자진행조기진단,염산다내고제대MCI환자진행조기치료능연완기진입AD적병정.
Objective To investigate the effect of donepezil hydrochloride on changes of cognitive functions and Montreal cognitive assessment (MoCA) scores in patients with mild cognitive impairment (MCI). Methods A total of 50 patients diagnosed as having MCI,admitted to our hospital from September 2010 to March 2011, were recruited; these patients were randomly assigned into treatment group (treated with donepezil hydrochloride,n=30) and control group (treated with Ginkgo biloba,n=20); the changes of MoCA scores were noted at 12 and 24 weeks after treatment.The data were analyzed by the statistical software SPSS 10.0. Results MoCA scores of treatment group 12 and 24 weeks after treatment were significantly higher than those before treatment (P＜0.05); MoCA scores of treatment group were significantly higher than those of control group 12 and 24 weeks after treatment (P＜0.05).Mann-Whitney rank sum test showed significant improvement in digit span,verbal fluency and delayed memory after the treatment of donepezil hydrochloride for 12 weeks as compared with those before treatment (P＜0.05). Conclusion By MoCA scale,MCI patients could get early diagnosis; MCI patients with early diagnosis and early application of donepezil hydrochloride will delay their entry into the course of AD.
