中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2009年
10期
907-912
,共6页
王晶%齐曼古丽·吾守尔%李霞%何元兵%克丽别娜·吐尔逊%文进%居来提·木塔力甫
王晶%齊曼古麗·吾守爾%李霞%何元兵%剋麗彆娜·吐爾遜%文進%居來提·木塔力甫
왕정%제만고려·오수이%리하%하원병%극려별나·토이손%문진%거래제·목탑력보
哮喘%维吾尔族%汉族%回归分析
哮喘%維吾爾族%漢族%迴歸分析
효천%유오이족%한족%회귀분석
Asthma%UYGUR NATIONALITY%HAN NATIONALITY%Regression analysis
目的 探讨新疆吐鲁番地区维吾尔族、汉族成人支气管哮喘(简称哮喘)发病的相关因素,分析可能存在的民族、地区差异.方法 收集吐鲁番地区医院确诊的哮喘患者166例,其中维吾尔族86例(维哮喘组),汉族80例(汉哮喘组)以同期眼科门诊患者为对照,按1:1配对设计.采用问卷调查,血清嗜酸细胞阳离子蛋白(S-ECP)、总IgE(T-IgE)及特异性IgE(S-IgE)检测,进行单因素及多因素条件logistic回归分析.调查结果与我国其他地区的研究资料进行比较.结果 呼吸道感染(OR_维=5.111,95%CI值:1.203~21.710;OR_汉=2.498,95%CI值:1.471~5.069)、家族史(OR_维=3.078,95%CI值:1.812~5.188;OR_汉=2.711,95%CI值:1.010~6.176)、过敏史(OR_维=2.083,95%CI值:1.043~4.162;OR_汉=3.998,95%CI值:1.739~9.198)、气候变化(OR_维=2.218,95%CI值:1.199~3.778;OR_汉=1.733,95%CI值:1.004~2.994)、S-IgE阳性(OR_维=1.592,95%CI值:1.018~2.491;OR_汉=3.858,95%CI值:2.246~8.507)与哮喘的关联有显著性.维哮喘组中呼吸道感染[59.30%(51/86)]、气候变化[36.05%(31/86)]诱发哮喘者高于汉哮喘组[分别为42.50%(34/80)和21.25%(17/80)];汉哮喘组中有过敏史[48.75%(39/80)]、S-IgE阳性者[52.50%(42/80)]高于维哮喘组[分别为32.56%(28/86)和30.23%(26/86)].中、重度哮喘患者血清炎症介质水平测定,S-ECP_维为(7.95±3.98)μg/L,S-ECP_汉为(11.21±4.74)μg/L;T-IgE_维为(72.23±45.92)kU/L,T-IgE_汉为(108.81±64.07)kU/L,均明显高于同民族对照[S-ECP_维为(1.94±1.16)μg/L,S-ECP_汉为(2.07±1.63)μg/L,T-IgE_维为(46.19±32.47)kU/L,T-IgE_汉为(50.97±38.51)kU/L;t值分别为8.96、10.52、2.81、4.97,P值均<0.01].汉族中、重度哮喘患者S-ECP和T-IgE水平均高于维吾尔族(t值3.01、2.68,P值均<0.01).结论 呼吸道感染、家族史、过敏史、气候变化、S-IgE阳性为吐鲁番地区哮喘发病的主要相关因素.中、重度哮喘发作的患者血清中S-ECP和T-IgE水平增高,汉族患者血清S-ECP、T-IgE水平高于维吾尔族.遗传,环境因素对哮喘的发生和发展有影响.
目的 探討新疆吐魯番地區維吾爾族、漢族成人支氣管哮喘(簡稱哮喘)髮病的相關因素,分析可能存在的民族、地區差異.方法 收集吐魯番地區醫院確診的哮喘患者166例,其中維吾爾族86例(維哮喘組),漢族80例(漢哮喘組)以同期眼科門診患者為對照,按1:1配對設計.採用問捲調查,血清嗜痠細胞暘離子蛋白(S-ECP)、總IgE(T-IgE)及特異性IgE(S-IgE)檢測,進行單因素及多因素條件logistic迴歸分析.調查結果與我國其他地區的研究資料進行比較.結果 呼吸道感染(OR_維=5.111,95%CI值:1.203~21.710;OR_漢=2.498,95%CI值:1.471~5.069)、傢族史(OR_維=3.078,95%CI值:1.812~5.188;OR_漢=2.711,95%CI值:1.010~6.176)、過敏史(OR_維=2.083,95%CI值:1.043~4.162;OR_漢=3.998,95%CI值:1.739~9.198)、氣候變化(OR_維=2.218,95%CI值:1.199~3.778;OR_漢=1.733,95%CI值:1.004~2.994)、S-IgE暘性(OR_維=1.592,95%CI值:1.018~2.491;OR_漢=3.858,95%CI值:2.246~8.507)與哮喘的關聯有顯著性.維哮喘組中呼吸道感染[59.30%(51/86)]、氣候變化[36.05%(31/86)]誘髮哮喘者高于漢哮喘組[分彆為42.50%(34/80)和21.25%(17/80)];漢哮喘組中有過敏史[48.75%(39/80)]、S-IgE暘性者[52.50%(42/80)]高于維哮喘組[分彆為32.56%(28/86)和30.23%(26/86)].中、重度哮喘患者血清炎癥介質水平測定,S-ECP_維為(7.95±3.98)μg/L,S-ECP_漢為(11.21±4.74)μg/L;T-IgE_維為(72.23±45.92)kU/L,T-IgE_漢為(108.81±64.07)kU/L,均明顯高于同民族對照[S-ECP_維為(1.94±1.16)μg/L,S-ECP_漢為(2.07±1.63)μg/L,T-IgE_維為(46.19±32.47)kU/L,T-IgE_漢為(50.97±38.51)kU/L;t值分彆為8.96、10.52、2.81、4.97,P值均<0.01].漢族中、重度哮喘患者S-ECP和T-IgE水平均高于維吾爾族(t值3.01、2.68,P值均<0.01).結論 呼吸道感染、傢族史、過敏史、氣候變化、S-IgE暘性為吐魯番地區哮喘髮病的主要相關因素.中、重度哮喘髮作的患者血清中S-ECP和T-IgE水平增高,漢族患者血清S-ECP、T-IgE水平高于維吾爾族.遺傳,環境因素對哮喘的髮生和髮展有影響.
목적 탐토신강토로번지구유오이족、한족성인지기관효천(간칭효천)발병적상관인소,분석가능존재적민족、지구차이.방법 수집토로번지구의원학진적효천환자166례,기중유오이족86례(유효천조),한족80례(한효천조)이동기안과문진환자위대조,안1:1배대설계.채용문권조사,혈청기산세포양리자단백(S-ECP)、총IgE(T-IgE)급특이성IgE(S-IgE)검측,진행단인소급다인소조건logistic회귀분석.조사결과여아국기타지구적연구자료진행비교.결과 호흡도감염(OR_유=5.111,95%CI치:1.203~21.710;OR_한=2.498,95%CI치:1.471~5.069)、가족사(OR_유=3.078,95%CI치:1.812~5.188;OR_한=2.711,95%CI치:1.010~6.176)、과민사(OR_유=2.083,95%CI치:1.043~4.162;OR_한=3.998,95%CI치:1.739~9.198)、기후변화(OR_유=2.218,95%CI치:1.199~3.778;OR_한=1.733,95%CI치:1.004~2.994)、S-IgE양성(OR_유=1.592,95%CI치:1.018~2.491;OR_한=3.858,95%CI치:2.246~8.507)여효천적관련유현저성.유효천조중호흡도감염[59.30%(51/86)]、기후변화[36.05%(31/86)]유발효천자고우한효천조[분별위42.50%(34/80)화21.25%(17/80)];한효천조중유과민사[48.75%(39/80)]、S-IgE양성자[52.50%(42/80)]고우유효천조[분별위32.56%(28/86)화30.23%(26/86)].중、중도효천환자혈청염증개질수평측정,S-ECP_유위(7.95±3.98)μg/L,S-ECP_한위(11.21±4.74)μg/L;T-IgE_유위(72.23±45.92)kU/L,T-IgE_한위(108.81±64.07)kU/L,균명현고우동민족대조[S-ECP_유위(1.94±1.16)μg/L,S-ECP_한위(2.07±1.63)μg/L,T-IgE_유위(46.19±32.47)kU/L,T-IgE_한위(50.97±38.51)kU/L;t치분별위8.96、10.52、2.81、4.97,P치균<0.01].한족중、중도효천환자S-ECP화T-IgE수평균고우유오이족(t치3.01、2.68,P치균<0.01).결론 호흡도감염、가족사、과민사、기후변화、S-IgE양성위토로번지구효천발병적주요상관인소.중、중도효천발작적환자혈청중S-ECP화T-IgE수평증고,한족환자혈청S-ECP、T-IgE수평고우유오이족.유전,배경인소대효천적발생화발전유영향.
Objective To analyze possible difference in bronchial asthma between ethnic and geographic groups and explore its correlates among Uygur and Han adults in Turpan Prefecture,Xinjiang. Methods One hundred and sixty-six clinically diagnosed asthmatic patients at Turpan Prefecture Hospital,Xinjiang,86 of Uygnr and 80 of Han ethnic,and 166 1:1 matched controls from ophthalmological outpatient department at the same hospital were recruited into the study. Interview with questionnaire was conducted and serum levels of eosinophilie cation protein (S-ECP),total IgE (T-IgE) and specific IgE (S-IgE) were measured for all of the participants to study related factors for asthma with univariate and multivariate conditional logistic regression analyses. Results Bronchial infection (OR_U=5.111,95% CI: 1. 203-21.710; OR_H=2. 498,95 % CI: 1.471-5. 069), family history of asthma (OR_U=3. 078,95% CI: 1. 812-5.188; OR_H=2. 711,95% CI: 1. 010-6. 176), personal allergy history (OR_U=2.083,95% CI: 1. 043-4. 162;OR_H=3. 998,95% CI: 1. 739-9. 198), weather change (OR_U=2.218,95% CI: 1. 199-3. 778;OR_H=1. 733,95% CI: 1. 004-2. 994) and positive S-IgE (OR_U=1. 592,95% CI: 1. 018-2. 491;OR_H=3. 858, 95% CI: 2. 246-8. 507) correlated with asthma in patients of both Uygur and Han ethnic. Percentage of asthma attack induced by respiratory infection [59. 30% (51/86)]and weather change [36. 05% (31/86)]in Uygur patients was significantly higher than that in Han ethnic [42. 50% (34/80) and 21.25% (17/80), respectively], but percentage of those with personal allergy history [48.75% (39/ 80)]and positive S-IgE [52.50% (42/80)]in Han ethnic was significantly higher than that in Uygur [32. 56% (28/86) and 30.23% (26/86), respectively]. Levels of S-ECP and T-IgE in patients with moderate and severe asthma of both Uygnr and Han ethnic [(S-ECP_U=7. 95±3.98) μg/L, S-ECP_H=(11.21±4.74)μg/L,T-IgE_U=(72. 23±45.92) kU/L,T-IgE_H=(108. 81±64.07) kU/L,respectively]were significantly higher than those in controls of the same ethnic [S-ECP_U=(1.94±1.16) μg/L, S-ECP_H=(2. 07±1.63)μ/L,T-IgE_U=(46.19±32.47) kU/L,T-IgE_H=(50. 97±38.51) kU/L;t values were 8.96,10.52,2.81,4.97, P<0.01], higher in Han ethnic than those in Uygur (t values were 3.01, 2. 68, P < 0. 01). Conclusion Bronchial infection,family asthma history, personal allergy history, weather change and positive S-IgE all were important correlates of asthma in Turpan Prefecture, Xinjiang. Levels of S-ECP and T-IgE in patients with moderate and severe asthma increased during its attacks, higher in Han ethnic than those in Uygur. Genetic and environmental factors may be involved in occurrence and development of asthma.