CAJ | 학술논문

目的研究188Re标记的肝癌单抗片段HAb18F(ab')2在荷肝癌裸鼠体内的药代动力学，求取药代动力学参数，建立药代动力学模型.方法 5组裸鼠经尾静脉注入1.85MBq188Re-HAb18F(ab')2，在不同时间点处死裸鼠，测量血及各脏器放射性计数.用3P97药代动力学软件处理188Re-HAb18F(ab')2给药后荷瘤鼠各时间点的血液放射性浓度及各主要脏器的放射性浓度，计算药代参数.结果 188Re-HAb18F(ab')2在裸鼠体内药代动力学参数分别为T1/22.29h,Vd1.49L,AUC20.49×109Bq·h·L-1,CL0.45×10-3L·h-1.188Re-HAb18F(ab')2特异性聚集于肿瘤中，在瘤体中以较高水平维持较长时间，在正常组织中代谢较快，主要从肾脏中排泄.结论 188Re-HAb18F(ab')2在荷肝癌裸鼠体内药代动力学符合线性一室模型.
목적 연구188Re표기적간암단항편단HAb18F(ab')2재하간암라서체내적약대동역학，구취약대동역학삼수，건립약대동역학모형.방법 5조라서경미정맥주입1.85MBq188Re-HAb18F(ab')2，재불동시간점처사라서，측량혈급각장기방사성계수.용3P97약대동역학연건처리188Re-HAb18F(ab')2급약후하류서각시간점적혈액방사성농도급각주요장기적방사성농도，계산약대삼수.결과 188Re-HAb18F(ab')2재라서체내약대동역학삼수분별위T1/22.29h,Vd1.49L,AUC20.49×109Bq·h·L-1,CL0.45×10-3L·h-1.188Re-HAb18F(ab')2특이성취집우종류중，재류체중이교고수평유지교장시간，재정상조직중대사교쾌，주요종신장중배설.결론 188Re-HAb18F(ab')2재하간암라서체내약대동역학부합선성일실모형.
AIM To establish the pharmacokinetic model of 188Re-HAb18F(ab')2and to evaluate its pharmacokinetic parameters. METHODS The mice was sacrificed at different time after 188Re-HAb18F(ab')2 i.v. injected into hepatoma-bearing nude mice. The blood and organs' radioactivity were measured. The concentrations of 188Re-HAb18F(ab')2 were evaluated with a pharmacokinetic 3P97 software. RESULTS Parameters of 188Re-HAb18F(ab')2 were T1/2 2.29 h, Vd 1.49 L，AUC 20.49×109 Bq·h·L-1, CL 0.45×10-3 L·h-1. 188Re-HAb18F(ab')2 was located specially in hepatoma with high selective reactivity of HAb18 F(ab')2. 188Re-HAb18F(ab')2 was mainly eliminated by kidney. CONCLUSION Pharmacokinetics of 188Re-HAb18F(ab')2 conforms to a l-compartment model.