CAJ | 학술논문

间充质干细胞(mesenchymal stem cells,MSCs)是具有自我更新和多向分化能力的多能干细胞,在不同的诱导条件下,可向成骨细胞、软骨细胞、心肌细胞、神经元等中胚层细胞分化,同时具有来源广泛、取材方便、可以体外大量扩增、免疫原性低等特点,尤其向内皮等分化的特性已使其成为血管组织工程的最佳种子细胞.目前间充质干细胞在心脏疾病、神经系统疾病、肾脏疾病等方面的科研及临床已有相关研究,展示出了广阔的前景.本文对间充质干细胞在血管工程中的机制及应用做一综述.
간충질간세포(mesenchymal stem cells,MSCs)시구유자아경신화다향분화능력적다능간세포,재불동적유도조건하,가향성골세포、연골세포、심기세포、신경원등중배층세포분화,동시구유래원엄범、취재방편、가이체외대량확증、면역원성저등특점,우기향내피등분화적특성이사기성위혈관조직공정적최가충자세포.목전간충질간세포재심장질병、신경계통질병、신장질병등방면적과연급림상이유상관연구,전시출료엄활적전경.본문대간충질간세포재혈관공정중적궤제급응용주일종술.
Mesenchymal stem cells ( MSCs) are multi - functional stem cells which are self - renewable and have multi - directional differentiation potential. Under various inducing conditions, they can be differentiated into mesoblastemas, such as osteoblasts, cartilage cells, cardiac muscle cells and neurocytes etc, and have the characteristics of wide availability, high resourcefulness, multi - differentiation in vitro and low immunogenicity. It is worthy of noting that their features of differen-tiation to endothelial cells have made the MSCs to be the most suitable seed cells in vascular tissue engineering. There have been some scientific and clinical researches on the MSC at present in heart diseases, nerve diseases and kidney and they have depicted very promising prospects.