CAJ | 학술논문

RNA干扰是一种由双链RNA引发的转录后基因沉默过程,目前已尝试将其应用于疾病治疗.但是在RNA干扰的应用研究中,最大的障碍是如何将小干扰RNA(siRNA)有效、安全地转运到靶组织和细胞.对近年来有关siRNA转运方式的研究进行综述,为寻求更好地转运方法提供可靠的依据.
RNA간우시일충유쌍련RNA인발적전록후기인침묵과정,목전이상시장기응용우질병치료.단시재RNA간우적응용연구중,최대적장애시여하장소간우RNA(siRNA)유효、안전지전운도파조직화세포.대근년래유관siRNA전운방식적연구진행종술,위심구경호지전운방법제공가고적의거.
RNA interference(RNAi)is a post-transcriptional gene-silencing phenomenon which is triggered by double-stranded RNA(dsRNA).Attempts age being made to exploit RNAi in a clinical setting.However,before RNAi can be exploited as therepeutically,several obstacles must be overcome such as the efficient and safe delivery of siRNA into target tissues and cells.Any usefull delivery method should be desinged to target siRNA.