CAJ | 학술논문

目的探讨屈光不正性弱视患儿枕叶皮质厚度改变.方法以1.5 T MR仪对9例屈光不正性弱视患儿及8名视力正常儿童进行全脑扫描,应用三维磁化准备快速梯度回波(3D MPRAGE)序列扫描,采集3D解剖数据,采用FreeSurfer软件进行处理分析.观察指标为双侧半球枕叶4个部位即楔叶、舌回、枕外侧叶和距状沟周边区的皮质厚度.结果屈光不正性弱视患儿双侧半球舌回、左侧距状沟周边区、右侧半球楔叶及枕外侧叶皮质厚度与对照组相比均明显变薄(P＜0.05).结论屈光不正性弱视儿童枕叶皮质存在形态学改变;通过对MR的3D解剖数据分析可以无创性衡量屈光不正性弱视患儿视觉相关枕叶皮质发育情况,具有潜在的临床应用价值.
목적 탐토굴광불정성약시환인침협피질후도개변.방법 이1.5 T MR의대9례굴광불정성약시환인급8명시력정상인동진행전뇌소묘,응용삼유자화준비쾌속제도회파(3D MPRAGE)서렬소묘,채집3D해부수거,채용FreeSurfer연건진행처리분석.관찰지표위쌍측반구침협4개부위즉설협、설회、침외측협화거상구주변구적피질후도.결과 굴광불정성약시환인쌍측반구설회、좌측거상구주변구、우측반구설협급침외측협피질후도여대조조상비균명현변박(P＜0.05).결론 굴광불정성약시인동침협피질존재형태학개변;통과대MR적3D해부수거분석가이무창성형량굴광불정성약시환인시각상관침협피질발육정황,구유잠재적림상응용개치.
Objective To study cortical thickness of the occipital lobe in children with ametropic amblyopia by using MRI technique and the FreeSurfer software.MethOds Nine children with ametropic amblyopia were included in the amblyopic group and 8 normal children were included in the control group.All the children underwent brain MRI on the Siemens Avanto 1.5 T scanner.For the cortical thickness analysis,3-demensional MPRAGE images were collected and analyzed with FreeSurfer software package.Cortical thickness of related regions in the occipital lobe (including the cuneus,later occipital,lingual,and pericalcarine gyri) were recorded and compared. Results The cortical thickness of the lingual,pericalcarine gyri on the left hemisphere and the cuneus,lateraloccipital,lingual gyri on the right hemisphere in amblyopic group were lower than the control group (P＜0.05). Conclusion Morphological changes existed in the occipital lobe in ametropic amblyopic children.The analysis technique with the FreeSurfer package has a potential value in the clinical application.