CAJ | 학술논문

目的用事件相关电位(ERP)技术研究长效纳曲酮缓释剂(LSRNTX)植入治疗对调节阿片类药物依赖患者情绪感受能力的作用.方法现场采集记录3组不同戒毒方式的阿片类药物依赖患者和正常对照组由3组不同情绪内涵的图片诱发的ERP波形.结果 ①LSRNTX治疗组植入6个月以上者中性图片诱发的P200波形的潜伏期为(197.27±41.30)ms,正常对照组为(196.36±42.50)ms,两者差异无显著性(P>0.05);而强制戒毒组为(213.91±37.18)ms,阿片类药物依赖对照组组为(216.00±41.52)ms,与正常对照组比较差异有显著性(P<0.01);②正性情绪图片的源定位分析发现,正常对照组P200源发生点在大脑前额叶皮质,LSRNTX治疗者的在内侧前额叶皮质后部;强制戒毒组和阿片类药物依赖对照组均在扣带回后部.结论 LSRNTX能使患者情绪感受产生的脑电ERP波形倾向正常化,正性图片诱发的P200的神经定位由阿片类药物依赖患者的扣带回升高至内侧前额叶皮质.
목적 용사건상관전위(ERP)기술연구장효납곡동완석제(LSRNTX)식입치료대조절아편류약물의뢰환자정서감수능력적작용.방법 현장채집기록3조불동계독방식적아편류약물의뢰환자화정상대조조유3조불동정서내함적도편유발적ERP파형.결과 ①LSRNTX치료조식입6개월이상자중성도편유발적P200파형적잠복기위(197.27±41.30)ms,정상대조조위(196.36±42.50)ms,량자차이무현저성(P>0.05);이강제계독조위(213.91±37.18)ms,아편류약물의뢰대조조조위(216.00±41.52)ms,여정상대조조비교차이유현저성(P<0.01);②정성정서도편적원정위분석발현,정상대조조P200원발생점재대뇌전액협피질,LSRNTX치료자적재내측전액협피질후부;강제계독조화아편류약물의뢰대조조균재구대회후부.결론 LSRNTX능사환자정서감수산생적뇌전ERP파형경향정상화,정성도편유발적P200적신경정위유아편류약물의뢰환자적구대회승고지내측전액협피질.
Objective To explore the effective of long-term sustained release naltrexone(LSRNTX)treatment for opioid dependences on their emotion.Methods The patients were divided into three groups:LSRNTX treatment group,incarcerated abstinent group and opioid dependence control group,and adding on healthy control group.Without any overt response on each picture subjects all were recorded scalp ERP when they saw three blocks pictures,including positive happy pictures,negative mutilated bodies,and neutral stimuli.Results Firstly,the latency of P200 elicited by neutral pictures in the group treated with LSRNTX over6 months WaS(197.27±41.30)ms and healthy control was(196.36±42.50)ms,which showed no significant different between two groups(P>0.05).But incarcerated abstinent group and opioid dependence control group showed a significantly worse condition(P＜0.01).Secondly,BESA results on happy pictures P200 showed that sources of P200 in healthy control group were located at prefrontal cortex,LSRNTX treatment group at medial prefrontal cortex,incarcerated abstinent group and opioid dependence control group both at posterior cingulate cortex.Conclusion Present study proved that LSRNTX implants group could lead to significantly better psychological conditions than incarcerated abstinent group and non-treating group.After LSRNTX implant treatment,the patients showed a trend toward normalization of neuronal function.