国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
INTERNATIONAL JOURNAL OF GENETICS
2012年
1期
31-36
,共6页
HLA%KIR%HCV
HLA%KIR%HCV
HLA%KIR%HCV
HLA%KIR%HCV
丙型肝炎是由丙型肝炎病毒(hepatitis C virus,HCV)感染导致的世界范围的感染性疾病,我国是高流行地区.多项研究表明:人类白细胞抗原(human leucocyte antigen,HLA)以及其特异配体-杀伤细胞免疫球蛋白样受体(killer cell immunoglobulin-like receptors,KIR)类型与HCV感染结局相关.HLA、KIR各自的多态性使得受体KIR与配体HLA的结合更为复杂化,二者结合的强弱以及KIR抑制性和激活性受体之间的平衡关系,直接影响了机体对HCV感染的免疫能力.该文将从HLA/KIR基因系统与HCV易感性,HLA/KIR基因系统与HCV自体清除的相关性以及它们在HCV感染进程中的作用三个方面来进行综述.
丙型肝炎是由丙型肝炎病毒(hepatitis C virus,HCV)感染導緻的世界範圍的感染性疾病,我國是高流行地區.多項研究錶明:人類白細胞抗原(human leucocyte antigen,HLA)以及其特異配體-殺傷細胞免疫毬蛋白樣受體(killer cell immunoglobulin-like receptors,KIR)類型與HCV感染結跼相關.HLA、KIR各自的多態性使得受體KIR與配體HLA的結閤更為複雜化,二者結閤的彊弱以及KIR抑製性和激活性受體之間的平衡關繫,直接影響瞭機體對HCV感染的免疫能力.該文將從HLA/KIR基因繫統與HCV易感性,HLA/KIR基因繫統與HCV自體清除的相關性以及它們在HCV感染進程中的作用三箇方麵來進行綜述.
병형간염시유병형간염병독(hepatitis C virus,HCV)감염도치적세계범위적감염성질병,아국시고류행지구.다항연구표명:인류백세포항원(human leucocyte antigen,HLA)이급기특이배체-살상세포면역구단백양수체(killer cell immunoglobulin-like receptors,KIR)류형여HCV감염결국상관.HLA、KIR각자적다태성사득수체KIR여배체HLA적결합경위복잡화,이자결합적강약이급KIR억제성화격활성수체지간적평형관계,직접영향료궤체대HCV감염적면역능력.해문장종HLA/KIR기인계통여HCV역감성,HLA/KIR기인계통여HCV자체청제적상관성이급타문재HCV감염진정중적작용삼개방면래진행종술.
Hepatitis C virus(HCV) infection is widely prevailed in the world.China is one of the high epidemic region.Previous studies have suggested that human leucocyte Antigen(HLA) and killer cell immunoglobulin-like receptors(KIR) are associated with HCV infection.The capability of different HLA and KIR combination,which may become more complicated by the high polymorphism of HLA and KIR genes,as well as the balance between inhibitory and activating KIR receptors,may impact on the immune response to HCV infection.This article summarized the recent advance of susceptibility,spontaneous clearance and developing of HCV infection assocoiacted with HLA/KIR gene system.
