中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2010年
5期
440-443
,共4页
覃青%傅一笑%蒙华庆%李涛%陈品红%欧颖%罗庆华%杜莲%邱海棠%高玉峰%郑玉萍%邱田
覃青%傅一笑%矇華慶%李濤%陳品紅%歐穎%囉慶華%杜蓮%邱海棠%高玉峰%鄭玉萍%邱田
담청%부일소%몽화경%리도%진품홍%구영%라경화%두련%구해당%고옥봉%정옥평%구전
双生子%精神健康发育%遗传%发育和健康状况评定
雙生子%精神健康髮育%遺傳%髮育和健康狀況評定
쌍생자%정신건강발육%유전%발육화건강상황평정
Twins%The development of mental health%The self assessment of DAWBA
目的 了解遗传因素对青少年双生子精神健康发育的影响.方法 通过教委学校募集11岁以上的共同生活的青少年双生子.签写知情同意书后利用发育和健康状况评定(Development and Well-Bing Assessment,DAWBA)对双生子父母及11岁以上的双生子进行双生子精神健康发育状况的凋查,并重点分析11岁以上双生子自评版的DAWBA.通过采集双生子的颊黏膜标本提取DNA进行卵型鉴定.结果 DAWBA的情绪、行为症状及其症状产生的影响,计算机诊断的结果中显示情绪障碍中的分离性焦虑[同卵双生组相关系数r=0.200,P=0.28;异卵双生组(DZ)r=0.198,P=0.447].特殊恐怖症状(r MZ=0.440,P=0.013;r DZ=0.419,P=0.094)、特殊恐怖症状影响(r MZ=0.418,P=0.019;r DZ=0.262,P=0.310)、社交恐怖症状(r MZ=0.296,P=0.106;r DZ=-0.119,P=0.648)、抑郁症状(rMZ=0.556,P=0.001;r DZ=-0.254,P=0.325)及对立违抗/品行障碍(r MZ=0.503,P=0.014;r DZ=-0.270,P=0.295)及进食症状(r MZ=0.764,P=0.046;r DZ:-0.091,P=0.728),结果显示同卵双生组双生子相关系数大于异卵双生组.结论 影响青少年精神健康发育的因素中,遗传因素起到了一定的作用.
目的 瞭解遺傳因素對青少年雙生子精神健康髮育的影響.方法 通過教委學校募集11歲以上的共同生活的青少年雙生子.籤寫知情同意書後利用髮育和健康狀況評定(Development and Well-Bing Assessment,DAWBA)對雙生子父母及11歲以上的雙生子進行雙生子精神健康髮育狀況的凋查,併重點分析11歲以上雙生子自評版的DAWBA.通過採集雙生子的頰黏膜標本提取DNA進行卵型鑒定.結果 DAWBA的情緒、行為癥狀及其癥狀產生的影響,計算機診斷的結果中顯示情緒障礙中的分離性焦慮[同卵雙生組相關繫數r=0.200,P=0.28;異卵雙生組(DZ)r=0.198,P=0.447].特殊恐怖癥狀(r MZ=0.440,P=0.013;r DZ=0.419,P=0.094)、特殊恐怖癥狀影響(r MZ=0.418,P=0.019;r DZ=0.262,P=0.310)、社交恐怖癥狀(r MZ=0.296,P=0.106;r DZ=-0.119,P=0.648)、抑鬱癥狀(rMZ=0.556,P=0.001;r DZ=-0.254,P=0.325)及對立違抗/品行障礙(r MZ=0.503,P=0.014;r DZ=-0.270,P=0.295)及進食癥狀(r MZ=0.764,P=0.046;r DZ:-0.091,P=0.728),結果顯示同卵雙生組雙生子相關繫數大于異卵雙生組.結論 影響青少年精神健康髮育的因素中,遺傳因素起到瞭一定的作用.
목적 료해유전인소대청소년쌍생자정신건강발육적영향.방법 통과교위학교모집11세이상적공동생활적청소년쌍생자.첨사지정동의서후이용발육화건강상황평정(Development and Well-Bing Assessment,DAWBA)대쌍생자부모급11세이상적쌍생자진행쌍생자정신건강발육상황적조사,병중점분석11세이상쌍생자자평판적DAWBA.통과채집쌍생자적협점막표본제취DNA진행란형감정.결과 DAWBA적정서、행위증상급기증상산생적영향,계산궤진단적결과중현시정서장애중적분리성초필[동란쌍생조상관계수r=0.200,P=0.28;이란쌍생조(DZ)r=0.198,P=0.447].특수공포증상(r MZ=0.440,P=0.013;r DZ=0.419,P=0.094)、특수공포증상영향(r MZ=0.418,P=0.019;r DZ=0.262,P=0.310)、사교공포증상(r MZ=0.296,P=0.106;r DZ=-0.119,P=0.648)、억욱증상(rMZ=0.556,P=0.001;r DZ=-0.254,P=0.325)급대립위항/품행장애(r MZ=0.503,P=0.014;r DZ=-0.270,P=0.295)급진식증상(r MZ=0.764,P=0.046;r DZ:-0.091,P=0.728),결과현시동란쌍생조쌍생자상관계수대우이란쌍생조.결론 영향청소년정신건강발육적인소중,유전인소기도료일정적작용.
Objective To investigate the impact of genetic and environmental factors on mental health status in adolescents twins. Methods A total of 52 pairs of twins aged 11 years were recruited with support from educational committees and school. After the guardians of these twins had signed an informed consent form,the Chinese version growth and the state of health evaluation (Development and Well-Bing Assessment,DAWBA) carries on twins' mental health growth condition investigation to the twins of Age greater than 11-year-old,and focus on a-nalysis of DAWBA youth-assessment version of more than 11-year-old twins. Buccal mucosa samples were collected from all twins for DNA extraction and zygosity identification test. Results The mood, the behavior symptom and the symptom produced the influence of the DAWBA and in the computer diagnosis' s result showed that the intra-pair correlation coefficience of the emotional disorder(rMZ=0, 200, P = 0. 28; r DZ = 0. 198, P = 0. 447) (MZ means was monozygotic,DZ means was dizygotie, r means was correlation), the special phobia symptom(r MZ = 0.440, P = 0.013;rDZ =0.419, P=0.094),the social phobia (rMZ =0.2%, P = 0. 106; r DZ = -0.119, P = 0.648),the depressive symptom (rMZ =0.556, P=0.001; rDZ = -0.254, P=0.325), and the oppositional/con-duct disorder(rMZ =0.503, P = 0.014; rDZ = -0.270, P = 0.295),eating disorder(r MZ =0.764, P=0.046; rDZ = -0.091, P=0.728) in Monozygotic twins was more remarkable than that in dizygotie twin. Conclusion The genetic factors play the vital role in affects in the child twins' mental health growth.
