CAJ | 학술논문

目的观察改良CHOP方案治疗初治低Karnofsky评分非霍奇金淋巴瘤(NHL)患者的疗效.方法将20例初治低Karnofsky评分NHL患者随机分成治疗组和对照组,分别采用改良和标准CHOP方案进行治疗.结果经1个周期治疗后,治疗组13例中12例Karnofsky评分＞60分,1例仍＜ 60分,总有效率92.3％(12/13);对照组7例患者中,3例Karnofsky评分＞60分,4例仍＜60分,总有效率100.0％(7/7),对照组骨髓不良反应发生率为57.1％(4/7),两组间总有效率差异无统计学意义( P=0.4515),患者Karnofsky评分改善差异有统计学意义(P=0.0149).结论改良CHOP方案治疗初治的低Karnofsky评分NHL患者可以改善其Karnofsky评分,有利于患者的后期治疗和降低住院费用.
목적 관찰개량CHOP방안치료초치저Karnofsky평분비곽기금림파류(NHL)환자적료효.방법 장20례초치저Karnofsky평분NHL환자수궤분성치료조화대조조,분별채용개량화표준CHOP방안진행치료.결과 경1개주기치료후,치료조13례중12례Karnofsky평분＞60분,1례잉＜ 60분,총유효솔92.3％(12/13);대조조7례환자중,3례Karnofsky평분＞60분,4례잉＜60분,총유효솔100.0％(7/7),대조조골수불량반응발생솔위57.1％(4/7),량조간총유효솔차이무통계학의의( P=0.4515),환자Karnofsky평분개선차이유통계학의의(P=0.0149).결론 개량CHOP방안치료초치적저Karnofsky평분NHL환자가이개선기Karnofsky평분,유리우환자적후기치료화강저주원비용.
Objective To observe the effecacy of modified CHOP regimen in the initial treatment of non-Hodgkin' slymphoma (NHL) patients with low Karnofsky score.Methods Twenty initial treatment NHI.patients with low Karnofsky score were randomly allocated into treatment group and control group,respectively treated with modified and standard CHOP regimen.Results Of 13 cases in treatment group,12 pacients'Karnofsky score were over 60.1 was still below 60,overall response (OR) rate was 92.3 ％ (12/13).while in control group,3 patients' Karnofsky score were over 60,4 were still below 60.OR rate was 100 ％ (7/7),rate of marrow toxicity was 57.1 ％ (4/7).There were no significantly difference for OR rates (P =0.4515),but for improving Karnofsky score there were significantly difference (P =0.0149).Conclusion Modified CHOP regimen can improve Karnofsky score of NHL patients with low Karnofsky score,benefical for further treatment and reducing hospitalization cost.