CAJ | 학술논문

目的探讨COX-2、VEGF-C在人乳腺癌组织中的表达及其与淋巴转移之间的关系.方法运用免疫组织化学SABC法检测COX-2和VEGF-C在乳腺癌组织中的表达情况.结果 60例乳腺癌组织中COX-2和VEGF-C的表达阳性率分别为66.7%和60.0%,且二者表达呈正相关(r=0.429,P<0.05).COX-2阳性、VEGF-C阳性组淋巴转移的发生率(80.0%)明显高于COX-2阴性、VEGF-C阴性组(21.4%;P<0.05).结论 COX-2、VEGF-C在乳腺癌组织中呈过表达,呈正相关关系,且与乳腺癌的淋巴转移关系密切,COX-2表达上调可能促使VEGF-C的过表达,诱导肿瘤淋巴管的生成,从而导致乳腺癌细胞淋巴转移的发生.
목적 탐토COX-2、VEGF-C재인유선암조직중적표체급기여림파전이지간적관계.방법 운용면역조직화학SABC법검측COX-2화VEGF-C재유선암조직중적표체정황.결과 60례유선암조직중COX-2화VEGF-C적표체양성솔분별위66.7%화60.0%,차이자표체정정상관(r=0.429,P<0.05).COX-2양성、VEGF-C양성조림파전이적발생솔(80.0%)명현고우COX-2음성、VEGF-C음성조(21.4%;P<0.05).결론 COX-2、VEGF-C재유선암조직중정과표체,정정상관관계,차여유선암적림파전이관계밀절,COX-2표체상조가능촉사VEGF-C적과표체,유도종류림파관적생성,종이도치유선암세포림파전이적발생.
Objective To detect the expressions of COX-2 and VEGF-C in breast cancer and to explore the relationship between their expressions and lymphatic metastasis. Methods Immunohistochemical stai- ning (SABC) was used to detect the expressions of COX-2 and VEGF-C proteins in 60 cases of breast canc- er. Results The positive rate of COX-2 and VEGF-C in breast cancer were 66.7% and 60. 0%, and the expression of COX-2 was positively correlated with VEGF-C (r =0.429, P<0.05). COX-2 and VEGF-C expressions were positively correlated with lymphatic metastasis (P<0.05). The lymphatic metastasis rate in the positive group of COX-2 and VEGF-C were higher than that in the negative group of COX-2 and VEGF-C. Conclusion Over expression of COX-2 and VEGF-C were observed in breast cancer, and closely related to lymphatic metastasis. COX-2 has positive correlation with VEGF-C and was correlated with lym- phatic metastasis of breast cancer. COX-2 may promote the over expression of VEGF-C in tumor cells and cause lymphatic metastasis.