CAJ | 학술논문

本文比较分析了18例神经母细胞瘤的DNA含量、N-myc基因扩增、临床分期、原发部位等因素与预后的关系.结果表明,有N-myc基因扩增的死亡率(7/10)明显高于无扩增的(1/8);DNA含量增高与肿瘤的恶性度成正比;临床分期与N-myc基因扩增情况相结合与病死率的关系极为密切.
본문비교분석료18례신경모세포류적DNA함량、N-myc기인확증、림상분기、원발부위등인소여예후적관계.결과표명,유N-myc기인확증적사망솔(7/10)명현고우무확증적(1/8);DNA함량증고여종류적악성도성정비;림상분기여N-myc기인확증정황상결합여병사솔적관계겁위밀절.
In this study, 18 children with neuroblastoma were analysed on the relation among DNA content, N-myc gene amplification and the clinical staging. The results reveal; the mortality of patients with N-myc gene amplification (7/10) was higher than those without N-myc gene amplification (1/8); DNA content was related to malignancy of the tumor, combination of N-myc gene amplification and the clinical staging kept close link with the prognosis.