中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2011年
5期
390-393
,共4页
宋颖秋%王天禄%党军%陈延治%裘敬平%姚雷%李光
宋穎鞦%王天祿%黨軍%陳延治%裘敬平%姚雷%李光
송영추%왕천록%당군%진연치%구경평%요뢰%리광
体层摄影术,正电子发射%癌,非小细胞肺/放射疗法%放射疗法,三维适形%预后
體層攝影術,正電子髮射%癌,非小細胞肺/放射療法%放射療法,三維適形%預後
체층섭영술,정전자발사%암,비소세포폐/방사요법%방사요법,삼유괄형%예후
Tomography,positron-emission%Carcinoma,non-small-cell lung/radiotherapy%Radiotherapy,three-dimensional conformal%Prognosis
目的 探讨在PET-CT指导下行三维适形放疗(3DCRT)的Ⅲ期非小细胞肺癌(NSCLC)的疗效和预后因素。方法 对59例在PET-CT定位下行3DCRT的Ⅲ期NSCLC患者,采用Kaplan-Meier法计算生存率并Logrank法检验和单因素预后分析,对单因素分析有意义的因素进一步行Cox 模型多因素预后分析。结果 随访率为98％,随访满2年者为19例。1、2年生存率分别为66％、37％,中位生存期17个月。单因素分析结果显示影响预后的因素有吸烟、放疗剂量、大体肿瘤体积、SUV值、T分期、临床分期(x2=7.46、7.52、8.37、4.97、5.82、4.37,P=0.006、0.006、0.004、0.026、0.016、0.037)。Cox模型多因素分析显示影响预后的因素有吸烟、放疗剂量、大体肿瘤体积、临床分期(x2 =6.20、9.69、6.39、10.09,P=0.013、0.002、0.011、0.001)。结论 PET-CT定位下行3DCRT的Ⅲ期NSCLC患者的生存时间优于以往报道,吸烟、放疗剂量、大体肿瘤体积、临床分期是影响生存的因素。
目的 探討在PET-CT指導下行三維適形放療(3DCRT)的Ⅲ期非小細胞肺癌(NSCLC)的療效和預後因素。方法 對59例在PET-CT定位下行3DCRT的Ⅲ期NSCLC患者,採用Kaplan-Meier法計算生存率併Logrank法檢驗和單因素預後分析,對單因素分析有意義的因素進一步行Cox 模型多因素預後分析。結果 隨訪率為98％,隨訪滿2年者為19例。1、2年生存率分彆為66％、37％,中位生存期17箇月。單因素分析結果顯示影響預後的因素有吸煙、放療劑量、大體腫瘤體積、SUV值、T分期、臨床分期(x2=7.46、7.52、8.37、4.97、5.82、4.37,P=0.006、0.006、0.004、0.026、0.016、0.037)。Cox模型多因素分析顯示影響預後的因素有吸煙、放療劑量、大體腫瘤體積、臨床分期(x2 =6.20、9.69、6.39、10.09,P=0.013、0.002、0.011、0.001)。結論 PET-CT定位下行3DCRT的Ⅲ期NSCLC患者的生存時間優于以往報道,吸煙、放療劑量、大體腫瘤體積、臨床分期是影響生存的因素。
목적 탐토재PET-CT지도하행삼유괄형방료(3DCRT)적Ⅲ기비소세포폐암(NSCLC)적료효화예후인소。방법 대59례재PET-CT정위하행3DCRT적Ⅲ기NSCLC환자,채용Kaplan-Meier법계산생존솔병Logrank법검험화단인소예후분석,대단인소분석유의의적인소진일보행Cox 모형다인소예후분석。결과 수방솔위98％,수방만2년자위19례。1、2년생존솔분별위66％、37％,중위생존기17개월。단인소분석결과현시영향예후적인소유흡연、방료제량、대체종류체적、SUV치、T분기、림상분기(x2=7.46、7.52、8.37、4.97、5.82、4.37,P=0.006、0.006、0.004、0.026、0.016、0.037)。Cox모형다인소분석현시영향예후적인소유흡연、방료제량、대체종류체적、림상분기(x2 =6.20、9.69、6.39、10.09,P=0.013、0.002、0.011、0.001)。결론 PET-CT정위하행3DCRT적Ⅲ기NSCLC환자적생존시간우우이왕보도,흡연、방료제량、대체종류체적、림상분기시영향생존적인소。
Objective To investigate prognostic factors in Stage Ⅲ non-small cell lung cancer (NSCLC) treated with definitive radiation therapy (RT) with PET-CT-based radiotherapy planning. Methods Fifty nine patients with Stage Ⅲ NSCLC treated with radiation therapy of 60 Gy or more were enrolled into this study. The impact of prognostic factors on survival was evaluated by univariate and multivariate analyses. Results The following-up rate was 98％. Nineteen patients completed 2 years' followed-up. The overall l-year and 2-year survival rate was 66％ and 37％, respectively, with a median survival time of 17 months. At a univariate analysis, cigarette smoking status, T stage, radiation dose, the standardized uptake value, the gross tumor volume and clinical stage were significant prognostic factors ( x2 =7.46,7. 52,8.37,4. 97,5.82,4. 37, P =0. 006,0. 006,0. 004,0. 026,0. 016,0. 037, respectively ).At multivariate analyses, cigarette smoking status, radiation dose, gross tumor volume and clinical stage were significant prognostic factors ( x2 =6. 20, 9. 69, 6. 39, 10. 09, P =0. 013,0. 002, 0. 011,0. 001,respectively). Conclusions Cigarette smoking status, radiation dose, gross tumor volume and clinical stage are significant prognostic factors on survival in patients with Stage Ⅲ NSCLC treated with RT based on PET-CT radiotherapy planning.
