CAJ | 학술논문

目的探讨重度抑郁患者与正常对照者血浆催产素、皮质醇水平差异以及其与抑郁症状严重程度的关系.方法 18 ～45岁重度抑郁患者20人,正常对照26人分别接受血浆催产素、皮质醇水平测量,病例组评定汉密顿抑郁量表.结果非参数检验显示抑郁患者血浆催产素水平高于正常对照组[(213.60±164.29)pg/ml,(112.27±101.21) pg/ml,z=-2.306,P=0.021]；差异具有统计学意义.血浆催产素对数值与抑郁严重程度成正相关( r=0.599,P=0.005).病例组血浆皮质醇水平与正常对照组相比差异不具有统计学意义[ (0.131 ±0.089) pg/ul,(0.107±0.077) pg/ul,z=-0.920,P=0.358],但在抑郁患者中血浆皮质醇对数值与抑郁严重程度正相关( r=0.691,P=0.001).催产素水平对数值与皮质醇对数值成正相关( r=0.743,P＜0.001).多元线性回归模型分析显示重度抑郁患者中,催产素水平是影响抑郁严重程度的因素(校正R2 =0.358,F=11.578,P=0.003).结论与正常对照组相比,重度抑郁患者存在血浆催产素水平异常,血浆催产素水平可能是影响抑郁症状严重程度的因素,而皮质醇水平与抑郁严重程度的关系尚不能确定.
목적 탐토중도억욱환자여정상대조자혈장최산소、피질순수평차이이급기여억욱증상엄중정도적관계.방법 18 ～45세중도억욱환자20인,정상대조26인분별접수혈장최산소、피질순수평측량,병례조평정한밀돈억욱량표.결과 비삼수검험현시억욱환자혈장최산소수평고우정상대조조[(213.60±164.29)pg/ml,(112.27±101.21) pg/ml,z=-2.306,P=0.021]；차이구유통계학의의.혈장최산소대수치여억욱엄중정도성정상관( r=0.599,P=0.005).병례조혈장피질순수평여정상대조조상비차이불구유통계학의의[ (0.131 ±0.089) pg/ul,(0.107±0.077) pg/ul,z=-0.920,P=0.358],단재억욱환자중혈장피질순대수치여억욱엄중정도정상관( r=0.691,P=0.001).최산소수평대수치여피질순대수치성정상관( r=0.743,P＜0.001).다원선성회귀모형분석현시중도억욱환자중,최산소수평시영향억욱엄중정도적인소(교정R2 =0.358,F=11.578,P=0.003).결론 여정상대조조상비,중도억욱환자존재혈장최산소수평이상,혈장최산소수평가능시영향억욱증상엄중정도적인소,이피질순수평여억욱엄중정도적관계상불능학정.
Objective To explore the difference of the oxytocin Levels and cortisol levels between major depression patients and normal controls,and the relationship of symptoms severity of major depression with oxytocin levels and cortisol levels.Methods Twenty 18 ～ 45years old major depression patients and twenty six normal controls were tested by an enzyme-linked immunosorbent assay to evaluate the oxytocin levels and cortisol levels,and the Hamilton Rating Scale for Depression-17 item was used to evaluate the symptoms severity of depression in patient group.Results Mann-Whitney test showed there were significantly differences in oxytocin level between patients and controls ( ( 213.60 ± 164.29 ) pg/ml vs ( 112.27 ± 101.21 ) pg/ml,z =- 2.306,P =0.021 ),but there were no significantly differences in cortisol level between two groups.Within the depressive sample( (0.131± 0.089) vs (0.107 ± 0.077 ) pg/ul,z =- 0.920,P =0.358 ),the severity of depressive symptom was positive correlated to the value of oxytocin ( r=0.599,P=0.005) and cortisol( r=0.691,P=0.001 ),the value of oxytocin was also positive correlated to the value of cortisol( r =0.743,P ＜ 0.01 ),Multiple liner regression analyses showed that the value of oxytocin is an impact factor of the severity of depression.( adjusted R2 =0.358,F =11.578,P =0.003 ).Conclusion This study indicated that the value of plasma oxytocin maybe significantly differences between depression and normal controls and the plasma oxytocin level maybe a factor which influence the severity of major depression,the relationship of the cortisol value and the severity of depression can not be confirmed.