CAJ | 학술논문

目的探讨B型利钠肽(BNP)和超敏C反应蛋白(hs-CRP)在急性心肌梗死(AMI)检测中的价值.方法回顾性分析60例AMI患者和50例健康者的资料,观察BNP和hs-CRP在AMI和Killip分级中的表达特征,并探讨其与预后的关系.结果治疗前AMI组的BNP、hs-CRP和肌酸激酶同工酶(CK-MB)与对照组比较差异均有统计学意义(P＜0.05),AMI组治疗前后比较差异有统计学意义(P＜0.05).治疗前后BNP、hs-CRP与CK-MB呈正相关(r=0.892,r=0.683,均P＜0.05).BNP、hs-CRP和CK-MB水平随Killip分级的严重程度而升高,呈正相关.BNP、hs-CRP和CK-MB各级别比较差异有统计学意义(P＜0.01).60例中,8例(13.3%)死亡,单因素分析结果显示BNP(≥56.1 pmol/L)、hs-CRP(≥9.0 mg/L)、CK-MB(≥75.1 U/L)和Killip分级Ⅲ、Ⅳ级为AMI患者预后的不良因素(均P＜0.05).结论 BNP和hs-CRP为AMI较为敏感的生化指标,其检测对于AMI的诊断、病情评估及预后具有重要价值.
목적 탐토B형리납태(BNP)화초민C반응단백(hs-CRP)재급성심기경사(AMI)검측중적개치.방법 회고성분석60례AMI환자화50례건강자적자료,관찰BNP화hs-CRP재AMI화Killip분급중적표체특정,병탐토기여예후적관계.결과 치료전AMI조적BNP、hs-CRP화기산격매동공매(CK-MB)여대조조비교차이균유통계학의의(P＜0.05),AMI조치료전후비교차이유통계학의의(P＜0.05).치료전후BNP、hs-CRP여CK-MB정정상관(r=0.892,r=0.683,균P＜0.05).BNP、hs-CRP화CK-MB수평수Killip분급적엄중정도이승고,정정상관.BNP、hs-CRP화CK-MB각급별비교차이유통계학의의(P＜0.01).60례중,8례(13.3%)사망,단인소분석결과현시BNP(≥56.1 pmol/L)、hs-CRP(≥9.0 mg/L)、CK-MB(≥75.1 U/L)화Killip분급Ⅲ、Ⅳ급위AMI환자예후적불량인소(균P＜0.05).결론 BNP화hs-CRP위AMI교위민감적생화지표,기검측대우AMI적진단、병정평고급예후구유중요개치.
Objective To explore the clinical significance of determination of the serum levels of brain (B-type) natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP) in patients with acute myocardial infarction (AMI).Methods The clinical data of 60 cases with AMI and 50healthy controls were analyzed retrospectively.The BNP and hs-CRP levels were analyzed in AMI and Killip class,and their relationship with prognosis was investigated.Results The serum levels of BNP,hs-CRP and creatine kinase (CK)-MB) were higher in AMI group than in control group (all P＜0.05),and the levels were lowered after treatment (P＜0.05).The correlation analysis indicated that BNP and hs-CRP had positive correlations with CK-MB (r=0.892 and 0.683,all P＜0.05),and increased along with the severity of Killip classification.The 8 cases (13.3 % ) died,and single factor analysis revealed that BNP (≥56.1 pmol/L),hs-CRP (≥9.0 mg/L),CK-MB (≥75.1 U/L) and Killip classification (grade Ⅲ and Ⅳ) were the poor prognostic factors (P＜0.05).Conclusions The elevation of BNP and hs-CRP level is correlated with the severity of AMI,and could be used to evaluate the AMI patients' diagnosis and prognosis.