CAJ | 학술논문

本文简要介绍了诊疗用聚氨酯(PU)导管进入体内后的凝血过程，分析了影响凝血的部分因素，包括材料的硬度、表面电荷、光滑程度、亲疏水性和PU的微相分离结构等，本文还重点探讨了改善PU导管材料抗凝血性的途径和方法，涉及肝素化、亲水性修饰、白蛋白修饰、类肝素化以及日前逐渐兴起的磷酸盐修饰等。
본문간요개소료진료용취안지(PU)도관진입체내후적응혈과정，분석료영향응혈적부분인소，포괄재료적경도、표면전하、광활정도、친소수성화PU적미상분리결구등，본문환중점탐토료개선PU도관재료항응혈성적도경화방법，섭급간소화、친수성수식、백단백수식、류간소화이급일전축점흥기적린산염수식등。
This article briefly reviewed the blood coagulation procedure ofintravascular polyurethane catheters,factors influencing it including stiffness,surface charge,lubricity,hydrophilic-hydrophobic balance,and micro-separated phase structure of PU.Otherwise this paper discussed emphatically some traditional and recent attempts to improve the antithrombogenicity of polyurethane,such as heparin immobilization,increasing the surface hydrophilicity,protein conditioning,heparinoid modification, and attachment of other biological actives.