CAJ | 학술논문

目的观察2型糖尿病患者(T2DM)血清基质金属蛋白酶-9(MMP-9)、转化生长因子β1(TGF-β1)、IV型胶原(CIV)的变化,探讨其在糖尿病肾病(DN)进展中的作用. 方法根据尿白蛋白排泄率(UAER)将64例T2DM患者分为正常白蛋白尿(NA)组、微量蛋白尿(MA)组、临床白蛋白尿(ODN)组,分别检测各组的MMP-9、TGF-β1、CIV. 结果血清MMP-9含量在MA组及 ODN组较正常对照(NC)组明显升高(P<0.01),且ODN组较MA组明显升高(P<0.01).血清TGF-β1含量NA组、MA组及ODN组均较NC组明显升高(P<0.01),MA组及ODN组较NA组升高明显(P<0.01).血清C IV含量ODN组明显高于其他三组(P<0.01),NA组、MA组虽较NC组升高但无显著差异(P>0.05). 结论血清MMP-9、TGF-β1升高在DN的发生、发展中起着重要作用.
목적관찰2형당뇨병환자(T2DM)혈청기질금속단백매-9(MMP-9)、전화생장인자β1(TGF-β1)、IV형효원(CIV)적변화,탐토기재당뇨병신병(DN)진전중적작용. 방법근거뇨백단백배설솔(UAER)장64례T2DM환자분위정상백단백뇨(NA)조、미량단백뇨(MA)조、림상백단백뇨(ODN)조,분별검측각조적MMP-9、TGF-β1、CIV. 결과혈청MMP-9함량재MA조급 ODN조교정상대조(NC)조명현승고(P<0.01),차ODN조교MA조명현승고(P<0.01).혈청TGF-β1함량NA조、MA조급ODN조균교NC조명현승고(P<0.01),MA조급ODN조교NA조승고명현(P<0.01).혈청C IV함량ODN조명현고우기타삼조(P<0.01),NA조、MA조수교NC조승고단무현저차이(P>0.05). 결론혈청MMP-9、TGF-β1승고재DN적발생、발전중기착중요작용.
Objective To study whether serum matrix metalloproteinase 9, serum transforming growth factor β 1, serum type C IV collagen concentrations are alternatoin in various stages of patients with T2DM. Methods 64 cases T2DM patients were divided into three groups according to urine albumin excretion rate (UAER):normoalbuminuria (NA)group and microalbuminuria (MA) group and overt diabetic nephropathy (ODN)group. Serum MMP 9,TGF β 1 and C IV were detected in all cases. Results Serum MMP 9 in MA and ODN groups were higher than NA and normal control groups ( P <0.01);Serum TGF β 1 in NA,MA and ODN groups were higher than NC group( P <0.01); Serum C IV in ODN group was higher than other three groups( P <0.01)。 Conclusion Higher Serum MMP 9、TGF β 1 plays an important role in the development of diabetic nephropathy in T2DM.