食品与生物技术学报
食品與生物技術學報
식품여생물기술학보
JOURNAL OF FOOD SCIENCE AND BIOTECHNOLOGY
2010年
1期
40-43
,共4页
代国杰%朱建津%高琳琳%单立娟
代國傑%硃建津%高琳琳%單立娟
대국걸%주건진%고림림%단립연
褪黑素%LPS%IL-1%IL-10%MPO
褪黑素%LPS%IL-1%IL-10%MPO
퇴흑소%LPS%IL-1%IL-10%MPO
melatonin%lipopolysaccharide%interleukin 1%interleukin 10%myeloperoxidase(MPO)
研究脂多糖(LPS)刺激时,褪黑素对小鼠炎症反应的影响.用脂多糖建立炎症反应模型,检测肝脏中白介素-1(IL-1)、白介素-10(IL-10)水平,血清中一氧化氮(NO)、一氧化氮合酶(NOS)以及小肠髓过氧化物酶(MPO)的活性变化.在LPS刺激后4 h时,灌胃褪黑素的小鼠IL-1和小肠MPO明显低于灌胃生理盐水组和正常组,而IL-10高于灌胃生理盐水组和正常组,刺激后16 h时,IL-1、IL-10和MPO均较刺激后4 h有所降低.褪黑素对LPS所诱导的炎症反应有明显的抑制作用,有助于维持机体炎症/抗炎症平衡,保护机体免受炎症损伤.
研究脂多糖(LPS)刺激時,褪黑素對小鼠炎癥反應的影響.用脂多糖建立炎癥反應模型,檢測肝髒中白介素-1(IL-1)、白介素-10(IL-10)水平,血清中一氧化氮(NO)、一氧化氮閤酶(NOS)以及小腸髓過氧化物酶(MPO)的活性變化.在LPS刺激後4 h時,灌胃褪黑素的小鼠IL-1和小腸MPO明顯低于灌胃生理鹽水組和正常組,而IL-10高于灌胃生理鹽水組和正常組,刺激後16 h時,IL-1、IL-10和MPO均較刺激後4 h有所降低.褪黑素對LPS所誘導的炎癥反應有明顯的抑製作用,有助于維持機體炎癥/抗炎癥平衡,保護機體免受炎癥損傷.
연구지다당(LPS)자격시,퇴흑소대소서염증반응적영향.용지다당건립염증반응모형,검측간장중백개소-1(IL-1)、백개소-10(IL-10)수평,혈청중일양화담(NO)、일양화담합매(NOS)이급소장수과양화물매(MPO)적활성변화.재LPS자격후4 h시,관위퇴흑소적소서IL-1화소장MPO명현저우관위생리염수조화정상조,이IL-10고우관위생리염수조화정상조,자격후16 h시,IL-1、IL-10화MPO균교자격후4 h유소강저.퇴흑소대LPS소유도적염증반응유명현적억제작용,유조우유지궤체염증/항염증평형,보호궤체면수염증손상.
In this study, the physiological parameters of melatonin live, including inflammatory cytokine IL-1, IL-10 of spleen, intestinal myeloperoxidase (MPO) were determined after LPS treat. It was found that content of IL-1 and MPO activity decreased but IL-10 increased after 4 h stimulation by LPS. For the case of 16 h, the values of IL-1 , IL-10 and MPO activity were lower than that of 4 h. The results indicated melatonin can depress inflammation induced by LPS, maintain inflammatory and anti-inflammatory balance and protect animals from injury.
