CAJ | 학술논문

miRNA是广泛存在于真核生物的一种内源性的小分子RNA,作为一种关键因素与肿瘤的发生发展密切相关.miR-21是miRNA中具有代表性的基因,在多种肿瘤组织中过表达,这种一致的过表达提示miR-21基因有显著的致癌活性,在肿瘤中具有癌基因的功能.大量研究证实miR-21过表达可对消化道肿瘤的诊断、生物治疗和预后判断具有重要的指导意义.
miRNA시엄범존재우진핵생물적일충내원성적소분자RNA,작위일충관건인소여종류적발생발전밀절상관.miR-21시miRNA중구유대표성적기인,재다충종류조직중과표체,저충일치적과표체제시miR-21기인유현저적치암활성,재종류중구유암기인적공능.대량연구증실miR-21과표체가대소화도종류적진단、생물치료화예후판단구유중요적지도의의.
miRNAs are endogenous short RNA molecules widely distributed in eukaryotic organisms.They are closely related to tumor development. One good example is miR-21. It is overexpressed in a variety of tumor tissues, suggesting that miR-21 may have significant carcinogenic activities and act as a oncogene.Many studies confirm that overexpression of miR-21 has great indication in the development, diagnosis, biological treatment and prognosis of gastrointestinal cancer.