CAJ | 학술논문

目的探索我院耐药菌株的分布特征及规律,为临床早期制定治疗方案、合理应用抗生素提供依据.方法以765例患者共984株耐药菌为本次研究对象,对患者病历作回顾性调查,用SPSS 10.0进行统计学分析,X2 检验用于比较各组问率的差异.结果耐药菌株的分布以革兰阴性杆菌为主,主要分布于下呼吸道、生殖泌尿道;耐药菌在夏季分布比例最大;耐药菌在高龄患者分布比例最大.医院常见革兰阴性耐药菌呈多重耐药性.结论医院耐药菌主要分布于夏、春两季,且多分布于高龄患者,以革兰阴性杆菌为主,以下呼吸道、生殖泌尿道最为多见.医院耐药菌感染尤其多重耐药革兰阴性菌感染以亚胺培南/西司他丁、头孢哌酮/舒巴坦治疗为较佳方案.
목적 탐색아원내약균주적분포특정급규률,위림상조기제정치료방안、합리응용항생소제공의거.방법 이765례환자공984주내약균위본차연구대상,대환자병력작회고성조사,용SPSS 10.0진행통계학분석,X2 검험용우비교각조문솔적차이.결과 내약균주적분포이혁란음성간균위주,주요분포우하호흡도、생식비뇨도;내약균재하계분포비례최대;내약균재고령환자분포비례최대.의원상견혁란음성내약균정다중내약성.결론 의원내약균주요분포우하、춘량계,차다분포우고령환자,이혁란음성간균위주,이하호흡도、생식비뇨도최위다견.의원내약균감염우기다중내약혁란음성균감염이아알배남/서사타정、두포고동/서파탄치료위교가방안.
Objective To analyze the features and regularity of drug-resistant bacteria for basis in making therapeutic regimen and rational use of antibiotics in clinic.Methods A total of 984 strains of resistant bacteria isolated from 765 patients were tested.A retrospective study was performed on patients' case histories for the analysis on the distribution of resistant bacteria.Statistical analysis was made using SPSS 10.0 and the differences among groups were compared using X2 test.Results Of the total drug resistant strains,gram-negative resistant bacteria took the lead,and the bacteria were mostly seen in lower respiratory tract and genitourinary tract.Infection of drug-resistant bacteria occurred more often in summer and showed the highest percentage in elder patients.The common gram-negative resistant bacteria in the hospital were found to be multidrug resistant in most cases.Conclusions Resistant bacteria were mostly seen in summer and spring,and showed the highest proportion in elder patients.Gram-negative bacteria were the main species and mostly seen in lower respiratory tract and genitourinary tract.Imipenem-cilastatin,cefoperazone psulbactam were the optimal therapy for drug-resistant bacterial infection,much as in cases of muhidrug resistant gram-negative bacterial infection.