CAJ | 학술논문

目的比较甲磺酸瑞波西汀与氢溴酸西酞普兰治疗迟缓性抑郁症的疗效和安全性.方法将59例迟缓性抑郁症患者随机分为Ⅰ组(n=29)和Ⅱ组(n=30).Ⅰ、Ⅱ组治疗分别使用甲磺酸瑞波西汀和氢溴酸西酞普兰,两组疗程均为6周.使用汉密尔顿抑郁量表(HAMD)于治疗前及治疗第1、2、4、6周末各评定1次临床疗效;通过不良反应量表(TESS)、实验室检查、生命体征等观察药物安全性.结果治疗6周后,甲磺酸瑞波西汀组HAMD总分减分值为(18.48±6.38),氢溴酸西酞普兰组为(11.60±4.46),两组差异有统计学意义(P＜0.001).两组总有效率差异有统计学意义(82.8%与56.7%,P＜0.05),而不良反应差异无统计学意义.结论甲磺酸瑞波西汀治疗迟缓性抑郁症的疗效优于氢溴酸西酞普兰,是一种安全有效的抗抑郁药物.
목적 비교갑광산서파서정여경추산서태보란치료지완성억욱증적료효화안전성.방법 장59례지완성억욱증환자수궤분위Ⅰ조(n=29)화Ⅱ조(n=30).Ⅰ、Ⅱ조치료분별사용갑광산서파서정화경추산서태보란,량조료정균위6주.사용한밀이돈억욱량표(HAMD)우치료전급치료제1、2、4、6주말각평정1차림상료효;통과불량반응량표(TESS)、실험실검사、생명체정등관찰약물안전성.결과 치료6주후,갑광산서파서정조HAMD총분감분치위(18.48±6.38),경추산서태보란조위(11.60±4.46),량조차이유통계학의의(P＜0.001).량조총유효솔차이유통계학의의(82.8%여56.7%,P＜0.05),이불량반응차이무통계학의의.결론 갑광산서파서정치료지완성억욱증적료효우우경추산서태보란,시일충안전유효적항억욱약물.
Objective To study the efficacy and safety of reboxetine and citalopram in treating retardant depression.Methods A total of 59 patients with retardant depression were randomly divided into reboxetine group(n=29)and citalopram group(n=30)for the treatment of 6 weeks.The patients were assessed with the Hamilton depression scale(HAMD)and treatment emergent symptom scale(TESS).Results At the end of 6 weeks,the total scores of HAMD in reboxetine(18.48±6.38)group and citalopram(11.60±4.46)group both significantly decreased(P＜0.001).Between two groups,the efficacy(82.8% and 56.7%)had significant differences(P＜0.05)but side effects had no statistical significance.Conclusion Reboxetine has significant curative efficacy,milder adverse effects and higher safety for treating patients with retardant depression.