CAJ | 학술논문

目的研究极低出生体质量儿闪光刺激视觉诱发电位(FVEP)检测的临床意义.方法应用英国Oxford公司Medelecsynergy诱发电位仪对43例极低出生体质量儿进行FVEP检测,并选择56例正常足月儿做对照.结果极低出生体质量儿N1、P1、N2波潜伏期值分别为(181.43±26.73)ms、(217.27±26.54)ms、(249.21±26.49)ms,足月儿分别为(159.51±18.27)ms、(200.26±13.94)ms、(231.56±5.72)ms,两组比较差异有显著性(P＜0.05,P＜0.001).极低出生体质量儿P1波的异常率为75.6%,足月儿为0.极低出生体质量儿P1波异常相关影响因素的主效应模型为3.898-2.861颅内病变,颅内病变是独立影响因素(OR=0.057,95%CI 0.006～0.579,P=0.015).结论极低出生体质量儿FVEP检测P1波异常率高,FVEP异常改变与颅内病变关系密切.极低出生体质量儿在生后1个月内和矫正胎龄42周后至少进行两次FVEP检查,动态观察FVEP改变.
목적 연구겁저출생체질량인섬광자격시각유발전위(FVEP)검측적림상의의.방법 응용영국Oxford공사Medelecsynergy유발전위의대43례겁저출생체질량인진행FVEP검측,병선택56례정상족월인주대조.결과 겁저출생체질량인N1、P1、N2파잠복기치분별위(181.43±26.73)ms、(217.27±26.54)ms、(249.21±26.49)ms,족월인분별위(159.51±18.27)ms、(200.26±13.94)ms、(231.56±5.72)ms,량조비교차이유현저성(P＜0.05,P＜0.001).겁저출생체질량인P1파적이상솔위75.6%,족월인위0.겁저출생체질량인P1파이상상관영향인소적주효응모형위3.898-2.861로내병변,로내병변시독립영향인소(OR=0.057,95%CI 0.006～0.579,P=0.015).결론 겁저출생체질량인FVEP검측P1파이상솔고,FVEP이상개변여로내병변관계밀절.겁저출생체질량인재생후1개월내화교정태령42주후지소진행량차FVEP검사,동태관찰FVEP개변.
Objective To study the clinical significance of flash visual evoked potential(FVEP)detection in very low birth weight infants.Methods FVEP was performed in group of 43 very low birth weight infants with Medelecsynergy evoked potential instrument(Oxford Company,UK) comparing with the group of 56 term infants.Results The mean latency periods of N1,P1 and N2 waves in very low birth weight infant group were(181.43±26.73) ms,(217.27±26.54) ms,(249.21±26.49) ms respectively,while in term infant group were(159.51±18.27) ms,(200.26±13.94) ms,(231.56±15.72) ms.There were significant differences between two groups(P＜0.05,P＜0,001).The abnormal rates of main wave P1 were 75.6% and 0 respectively in very low birth weight infant group and term infant group.Furthermore,the major effect model for related influencing factors in very low birth weight infants with abnormal main wave was 3.898-2.861 intracranial lesion.Intracranial lesion was the independent risk factor for abnormal FVEP (0R=0.057,95% CI 0.006～0.579,P=0.015).Conclusion The abnormal rate of FVEP is higher in the very low birth weight infants,which is closely related to the intraeranial lesion.It is recomraended that FVEP is detected at least twice in the first month after birth or achieving the corrected gestational age of 42 weeks for dynamic observation.