CAJ | 학술논문

对136例年龄≥40岁、体重指数>24的2型糖尿病患者行血乳酸水平测定.服用小剂量与大剂量二甲双胍者(45与33例)的血乳酸水平明显高于未服用二甲双胍者(58例,t=2.314,2.511,均P<0.05),大小剂量者间差异无统计学意义;3组中均有血乳酸水平高于正常(>2.2 mmol/L)者,服用二甲双胍组多于未服者(X2=7.43,P<0.05),但均无>5.0 mmol/L者.提示在心肺肾功能正常的情况下,二甲双胍不会增加乳酸性酸中毒的风险.
대136례년령≥40세、체중지수>24적2형당뇨병환자행혈유산수평측정.복용소제량여대제량이갑쌍고자(45여33례)적혈유산수평명현고우미복용이갑쌍고자(58례,t=2.314,2.511,균P<0.05),대소제량자간차이무통계학의의;3조중균유혈유산수평고우정상(>2.2 mmol/L)자,복용이갑쌍고조다우미복자(X2=7.43,P<0.05),단균무>5.0 mmol/L자.제시재심폐신공능정상적정황하,이갑쌍고불회증가유산성산중독적풍험.
One hundred and thirty-six adult patients with type 2 diabetes ( ≥40 years, body mass index > 24) were assigned to the low-dose Mefformin, high-dose Mefformin, and control groups. Plasma lactic acid level was detected with ultraviolet enzyme kinetics assay. Our data showed that plasma lactic acid of the low-dose or high-dose mefformin group was significantly higher than the control group (2.314 vs. 2.511, P<0.05 ), although there was no significant difference between the low-dose and the high-dose Mefformin group. In all the 3 groups, increased lactic acid ( > 2. 2 mmol/L) was found in some patients ( Mefformin group vs. Control group: X2 = 7.43, P < 0.05 ), and no lactic acid > 5.0 mmol/L was found. Insulin resistance index and hemoglobin Alc were similar between the 3 groups. Thus, mefformin may not increase the risk of lactic acidosis in diabetic patients with normal cardiorespiratory and renal function.