中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2009年
9期
12-13
,共2页
抗环瓜氨酸肽抗体%类风湿因子%类风湿性关节炎
抗環瓜氨痠肽抗體%類風濕因子%類風濕性關節炎
항배과안산태항체%류풍습인자%류풍습성관절염
Anti -cyclic citrullinated peptide antibody%Rheumatoid factor%Rheumatoid arthritis
目的 探讨抗环瓜氨酸肽抗体(抗-CCP)和类风湿因子IgG-Rf联合检测对类风湿关节炎(RA)的诊断价值.方法 抗-CCP采用ELISA法定量检测,IgG一Rf采用速率散射免疫比浊法检测.结果 68例RA患者抗-CCP、IgG-Rf的灵敏度分别为57.4%和69.1%,61例非RA患者抗-CCP、IgG-Rf的特异度分别为97.6%和89.7%,两者联合检测灵敏度和特异度为30.9%和100%,21例IgG-Rf阴性中有6例抗-CCP阳性,阳性率为28.6%,47例IgG-Rf阳性中有42例抗-CCP阳性,阳性率为89.4%.结论 抗-CCP抗体能提高RA的早期诊断率,两者联合检测在RA诊断中可降低RA误诊率,同时提高RA诊断的特异性和阳性预测值.
目的 探討抗環瓜氨痠肽抗體(抗-CCP)和類風濕因子IgG-Rf聯閤檢測對類風濕關節炎(RA)的診斷價值.方法 抗-CCP採用ELISA法定量檢測,IgG一Rf採用速率散射免疫比濁法檢測.結果 68例RA患者抗-CCP、IgG-Rf的靈敏度分彆為57.4%和69.1%,61例非RA患者抗-CCP、IgG-Rf的特異度分彆為97.6%和89.7%,兩者聯閤檢測靈敏度和特異度為30.9%和100%,21例IgG-Rf陰性中有6例抗-CCP暘性,暘性率為28.6%,47例IgG-Rf暘性中有42例抗-CCP暘性,暘性率為89.4%.結論 抗-CCP抗體能提高RA的早期診斷率,兩者聯閤檢測在RA診斷中可降低RA誤診率,同時提高RA診斷的特異性和暘性預測值.
목적 탐토항배과안산태항체(항-CCP)화류풍습인자IgG-Rf연합검측대류풍습관절염(RA)적진단개치.방법 항-CCP채용ELISA법정량검측,IgG일Rf채용속솔산사면역비탁법검측.결과 68례RA환자항-CCP、IgG-Rf적령민도분별위57.4%화69.1%,61례비RA환자항-CCP、IgG-Rf적특이도분별위97.6%화89.7%,량자연합검측령민도화특이도위30.9%화100%,21례IgG-Rf음성중유6례항-CCP양성,양성솔위28.6%,47례IgG-Rf양성중유42례항-CCP양성,양성솔위89.4%.결론 항-CCP항체능제고RA적조기진단솔,량자연합검측재RA진단중가강저RA오진솔,동시제고RA진단적특이성화양성예측치.
Objective To explore the clinical value of the combined detection of anti - cyclic Cit-rullinated peptide(anti-CCP) antibody and rheumatoid factor (Rf) in the diagnosis of rheumatoid arthritis (RA). Methods Anti- CCP antibody was measured by ELISA and IgG- Rf were detected by rate nephe-lometry. Results In 68 patients with RA the sensitivity for anti - CCP antibody and IgG - Rf were 57.4%and 69.1% respectively. In 61 non-RA patients the speciality for anti -CCP was 97. 6% ,and for IgG- Rfwas 89.7%. If combined the detection of anti -CCP antibody and IgG -Rf,the sensitivity reached 30.9% ,the speciality reached 100%. In 21 patients with negative IgG - Rf 6 cases were anti - CCP antibody positive, the positive rate was 28.6%. In 47 patients with positive IgG - Rf 42 cases were anti - CCP antibody positive, the positive rate was 89.4%. Conclusions Anti -CCP antibody could improve the accuracy of early diagnosis of RA. The combined detection of anti - CCP antibody and IgG - Rf could reduce the misdiagnosis of RA. Mean-time the speciality and the positive predicative value could be raised.
