CAJ | 학술논문

目的探讨原发性肝癌术后复发与性激素水平的关系.方法采用放射免疫固相法检测正常对照(n=10例)组,肝硬化(n=10例)组及肝癌(n=42例)组患者术前血中雌二醇( E2) 及睾酮( T) 的含量,并对肝癌组患者术后1周、1月、6月、12月时E2及T含量进行检测.结果术前血浆E2、T水平在肝硬化、肝癌及对照组中无显著差异,但E2/T在肝癌组中较其他2组有显著增高;肝癌组术后E2/T水平有下降趋势,至术后6月时再次升高,而肝癌复发患者E2/T值在术后6月、12月时再次显著升高(P＜0.05).结论肝癌复发可能与性激素比例失衡有关.
목적 탐토원발성간암술후복발여성격소수평적관계.방법 채용방사면역고상법검측정상대조(n=10례)조,간경화(n=10례)조급간암(n=42례)조환자술전혈중자이순( E2) 급고동( T) 적함량,병대간암조환자술후1주、1월、6월、12월시E2급T함량진행검측.결과 술전혈장E2、T수평재간경화、간암급대조조중무현저차이,단E2/T재간암조중교기타2조유현저증고;간암조술후E2/T수평유하강추세,지술후6월시재차승고,이간암복발환자E2/T치재술후6월、12월시재차현저승고(P＜0.05).결론 간암복발가능여성격소비례실형유관.
Objective To investigate the relationship between sex hormone level and the recurrence of hepatocellular carcinoma.Methods The serum level of estradiol (E2) and testosterone(T) were detected in hepatocellular carcinoma patients (n=42),liver cirrhosis patients (n=10) and control group (n=10) by a solid phase radioimmunoassay method.The serum level of E2 and T were also detected in postoperative 1 week,1 month,6 months and 12 months in hepatocellular carcinoma patients.Results The level of E2 and T had no significantly difference among three groups.While the E2/T ratio was significantly higher in hepatocellular carcinoma than other two groups.The E2/T ratio decreased after operation,but it increased in postoperative 6 months in hepatocellular carcinoma.The E2/T ratio increased significantly in postoperative 6 months and 12 months in patients with recurrence(P＜0.05).Conclusion The recurrence of hepatocellular carcinoma may be related with the unbalance of sex hormone.