日用化学工业
日用化學工業
일용화학공업
CHINA SURFACTANT DETERGENT & CONSMETICS
2009年
6期
405-408
,共4页
肉豆蔻酸异丙酯%肉豆蔻酸%脂肪酶%合成
肉豆蔻痠異丙酯%肉豆蔻痠%脂肪酶%閤成
육두구산이병지%육두구산%지방매%합성
isopropyl myristate%myristic acid%lipase%synthesis
采用固定化脂肪酶(Novozym 435)在有机溶剂体系中催化肉豆蔻酸和异丙醇酯化合成了肉豆蔻酸异丙酯.研究了各种因素如有机溶剂种类、反应物摩尔比、反应温度及酶用量等因素对酯化率的影响.结果表明,肉豆蔻酸异丙酯合成的较佳条件为:1.14 g肉豆蔻酸,0.45 g异丙醇,0.02 g Novozym 435,10 mL石油醚(其中加入0.5 g 3A分子筛吸水),在55℃下振荡反应4 h,酯化率为99.2%(肉豆蔻酸可基本完全转化为肉豆蔻酸异丙酯).实验过程中固定化酶稳定性较好,可连续使用7批左右.
採用固定化脂肪酶(Novozym 435)在有機溶劑體繫中催化肉豆蔻痠和異丙醇酯化閤成瞭肉豆蔻痠異丙酯.研究瞭各種因素如有機溶劑種類、反應物摩爾比、反應溫度及酶用量等因素對酯化率的影響.結果錶明,肉豆蔻痠異丙酯閤成的較佳條件為:1.14 g肉豆蔻痠,0.45 g異丙醇,0.02 g Novozym 435,10 mL石油醚(其中加入0.5 g 3A分子篩吸水),在55℃下振盪反應4 h,酯化率為99.2%(肉豆蔻痠可基本完全轉化為肉豆蔻痠異丙酯).實驗過程中固定化酶穩定性較好,可連續使用7批左右.
채용고정화지방매(Novozym 435)재유궤용제체계중최화육두구산화이병순지화합성료육두구산이병지.연구료각충인소여유궤용제충류、반응물마이비、반응온도급매용량등인소대지화솔적영향.결과표명,육두구산이병지합성적교가조건위:1.14 g육두구산,0.45 g이병순,0.02 g Novozym 435,10 mL석유미(기중가입0.5 g 3A분자사흡수),재55℃하진탕반응4 h,지화솔위99.2%(육두구산가기본완전전화위육두구산이병지).실험과정중고정화매은정성교호,가련속사용7비좌우.
Isopropyl myristate was synthesized by the esterification of myristic acid with isopropanol using immobilized lipase (Novozym 435) as catalyst and an organic solvent as a reaction medium. The effects of solvent, molar ratio of substratcs, reaction temperature and dosage of the catalyst were investigated. Molecular sieve 3A was added into the reaction system to remove the water produced during the esterification and increased dramatically the esterification yield to make myristic acid react thoroughly. The optimized reaction conditions were as follows: 1.14 g myristic acid,0.45 g isopropanol,0. 02 g Novozym 435,0. 5 g 3A molecular sieve, 10 mL petroleum ether, at 55 ℃ for 4 h under oscillation condition. As the reaction process was stopped, 99. 2% of myristic acid was converted into isopropyl myristate. The immobilized lipase can be reused for at least 7 times.