中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2001年
2期
71-74
,共4页
单忠艳%滕卫平%李玉姝%王占乙%金迎%关海霞%滕晓春%杨帆%高天舒%王微波%史晓光%佟雅洁%陈威
單忠豔%滕衛平%李玉姝%王佔乙%金迎%關海霞%滕曉春%楊帆%高天舒%王微波%史曉光%佟雅潔%陳威
단충염%등위평%리옥주%왕점을%금영%관해하%등효춘%양범%고천서%왕미파%사효광%동아길%진위
碘%甲状腺功能减退症%流行病学研究
碘%甲狀腺功能減退癥%流行病學研究
전%갑상선공능감퇴증%류행병학연구
目的 研究不同碘摄入量人群的临床甲减和亚临床甲减患病率。方法 选择盘山、彰武和黄骅3个农村社区(分别为低碘、适碘和高碘地区)，在入户问卷调查的基础上行采样调查。共问卷调查16 287人，采样3 761人。所有采样调查对象接受体格检查、测定血清TSH、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)和甲状腺球蛋白(TG)、测定尿碘浓度及进行甲状腺B超检查。TSH异常者测定FT4、FT3和TSH受体抗体(TRAb)。结果 盘山、彰武和黄骅社区成人尿碘水平分别为103.1 μg/L、374.8 μg/L和614.6 μg/L。盘山、彰武和黄骅社区临床甲减患病率分别为0.27%、0.95%和2.05%；亚临床甲减的患病率分别为0.91%、2.90%和5.96%。引起临床甲减的主要原因是自身免疫性甲状腺炎，亚临床甲减中三分之一患者甲状腺自身抗体阳性。结论 横断面的流行病学对比研究证实碘摄入量增加有可能导致甲状腺功能减退症患病率增加。
目的 研究不同碘攝入量人群的臨床甲減和亞臨床甲減患病率。方法 選擇盤山、彰武和黃驊3箇農村社區(分彆為低碘、適碘和高碘地區)，在入戶問捲調查的基礎上行採樣調查。共問捲調查16 287人，採樣3 761人。所有採樣調查對象接受體格檢查、測定血清TSH、甲狀腺過氧化物酶抗體(TPOAb)、甲狀腺毬蛋白抗體(TGAb)和甲狀腺毬蛋白(TG)、測定尿碘濃度及進行甲狀腺B超檢查。TSH異常者測定FT4、FT3和TSH受體抗體(TRAb)。結果 盤山、彰武和黃驊社區成人尿碘水平分彆為103.1 μg/L、374.8 μg/L和614.6 μg/L。盤山、彰武和黃驊社區臨床甲減患病率分彆為0.27%、0.95%和2.05%；亞臨床甲減的患病率分彆為0.91%、2.90%和5.96%。引起臨床甲減的主要原因是自身免疫性甲狀腺炎，亞臨床甲減中三分之一患者甲狀腺自身抗體暘性。結論 橫斷麵的流行病學對比研究證實碘攝入量增加有可能導緻甲狀腺功能減退癥患病率增加。
목적 연구불동전섭입량인군적림상갑감화아림상갑감환병솔。방법 선택반산、창무화황화3개농촌사구(분별위저전、괄전화고전지구)，재입호문권조사적기출상행채양조사。공문권조사16 287인，채양3 761인。소유채양조사대상접수체격검사、측정혈청TSH、갑상선과양화물매항체(TPOAb)、갑상선구단백항체(TGAb)화갑상선구단백(TG)、측정뇨전농도급진행갑상선B초검사。TSH이상자측정FT4、FT3화TSH수체항체(TRAb)。결과 반산、창무화황화사구성인뇨전수평분별위103.1 μg/L、374.8 μg/L화614.6 μg/L。반산、창무화황화사구림상갑감환병솔분별위0.27%、0.95%화2.05%；아림상갑감적환병솔분별위0.91%、2.90%화5.96%。인기림상갑감적주요원인시자신면역성갑상선염，아림상갑감중삼분지일환자갑상선자신항체양성。결론 횡단면적류행병학대비연구증실전섭입량증가유가능도치갑상선공능감퇴증환병솔증가。
Objective To investigate the prevalence of overt and subclinical hypothyroidism in the areas with different iodine intakes. Methods A cross-sectional epidemiologic study in 3 rural communities of Panshan (iodine-deficient), Zhangwu (covered by iodinated salt from 1996) and Huanghua (iodine excessive) was performed. In these communities, 4 343, 7 714 and 4 230 inhabitants were respectively questioned about thyroid disorders. Of them 1 103, 1 584 and 1 074 were physically examined and sera were sampled. The measurements included TSH, thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) in the sera. The serum FT4, FT3 and TSH receptor antibody (TRAb) were determined for the subjects with abnormal TSH. Urinary iodine concentration and thyroid ultrasounic imaging were also examined. Results The median urinary iodine (MUI) was 103.1 μg/L in Panshan, 374.8 μg/L in Zhangwu and 614.6 μg/L in Huanghua. The prevalence of overt hypothyroidism was 0.27%, 0.95% and 2.05%in Panshan, Zhangwu and Huanghua, respectively. Overt hypothyroidism occured more frequently in the women over 45 years. The prevalence of subclinical hypothyroidism was 0.91%, 2.90% and 5.96% in Panshan, Zhangwu and Huanghua, respectively. The main cause of overt hypothyroidism was autoimmune thyroiditis; One third of the cases with subclinical hypothyroidism showed positive thyroid autoantibodies. Conclusion Higher prevalence of overt and subclinical hypothyroidism was found in the rural communities with higher iodine supply in a cross-sectional epidemiologic study, suggesting a possible role of increasing or exessive iodine intake in hypothroidism.
