国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
INTERNATIONAL JOURNAL OF GENETICS
2009年
2期
120-122
,共3页
ASPP2%P53家族%转录激活辅因子%细胞凋亡
ASPP2%P53傢族%轉錄激活輔因子%細胞凋亡
ASPP2%P53가족%전록격활보인자%세포조망
ASPP2%P53 family%Cofactor%Apoptosis
P53凋亡激活蛋白2(apoptosis stimulating proteins of P53 2,ASPP2)作为P53家族共同转录激活辅因子能和p53野生型、p63和p73结合,并促进其对下游促凋亡靶基因的转录,促进细胞凋亡.研究表明ASPP2参与细胞生长,凋亡以及损伤应激等一系列的生理反应,对研究肿瘤发生和治疗具有重要意义.
P53凋亡激活蛋白2(apoptosis stimulating proteins of P53 2,ASPP2)作為P53傢族共同轉錄激活輔因子能和p53野生型、p63和p73結閤,併促進其對下遊促凋亡靶基因的轉錄,促進細胞凋亡.研究錶明ASPP2參與細胞生長,凋亡以及損傷應激等一繫列的生理反應,對研究腫瘤髮生和治療具有重要意義.
P53조망격활단백2(apoptosis stimulating proteins of P53 2,ASPP2)작위P53가족공동전록격활보인자능화p53야생형、p63화p73결합,병촉진기대하유촉조망파기인적전록,촉진세포조망.연구표명ASPP2삼여세포생장,조망이급손상응격등일계렬적생리반응,대연구종류발생화치료구유중요의의.
ASPP2 is a member of the ASPP family.As a cofactor of P53 family,it can activate and transcribe them,especially to pro-apoptosis factor,and can promote cell apoptosis.It has been suggested that ASPP2 is oncogene in human tumors.This article roviews the current research progress of ASPP2.
